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" Sex and the origins of death / "
by William R. Clark.
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BL
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| Record Number
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623622
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| Doc. No
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dltt
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| Main Entry
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Clark, William R.,1938-
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| Title & Author
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Sex and the origins of death /\ by William R. Clark.
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| Publication Statement
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New York :: Oxford University Press,, 1996.
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| Page. NO
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xii, 190 p. :: ill. ;; 22 cm.
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| ISBN
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019510644X (cloth : alk. paper)
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: 9780195106442 (cloth : alk. paper)
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| Bibliographies/Indexes
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Includes bibliographical references (p. 181-185) and index.
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| Contents
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Death of a cell -- A second face of death -- Sex, segregation, and the origins of cellular death -- From sex to death: the puzzle of senescence -- A hierarchy of cells: the definition of brain death -- Standing at the abyss: viruses, spores and the meaning of life -- Coming to closure.
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| Abstract
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Why death? Is death an inextricable consequence of life? If not, where did death come from? In Sex and the Origins of Death, William R. Clark looks at life and death at the level of individual cells to address questions such as why we age, why cells die, and why sex and death seem to go hand in hand. Why must we die? To shed light on this question, Clark reaches far back in evolutionary history, to the moment when "inevitable death" (death from aging) first appeared. For cells during the first billion years, death, when it occurred, was accidental; there was nothing programmed into them that said they must die. But fierce competition gradually led to multicellular animals - size being an advantage against predators - and with this change came cell specialization and, most important, germ cells in which reproductive DNA was segregated from the DNA used to operate individual cells. When sexual reproduction evolved, it became the dominant form of reproduction on the planet, in part because mixing DNA from two individuals generates altogether new germline DNA. During this process, most mutations that have crept into the germline are corrected. But this does not happen in the other (somatic) cells of the body; the mutations are not corrected, and continue to accumulate. The somatic cells become, from a genetic point of view, both superfluous and dangerous. Nature's solution to this dilemma, Clark concludes, was programmed death - the somatic cells must die. Unfortunately, we are the somatic cells. Death is necessary to exploit to the fullest the advantages of sexual reproduction.
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| Subject
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Cell death.
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Death (Biology)
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Apoptosis.
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Sex (Biology)
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Cell Death.
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Death.
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Apoptosis.
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Cell Division.
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| LC Classification
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QH671.C56 1996
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