| Document Type
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BL
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| Record Number
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624387
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| Doc. No
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dltt
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| Main Entry
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Pecorino, Lauren
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| Title & Author
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Molecular biology of cancer : : mechanisms, targets, and therapeutics /\ Lauren Pecorino
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| Edition Statement
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3rd ed
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| Publication Statement
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Oxford :: Oxford University Press,, c2012
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| Page. NO
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xviii, 342 p. :: ill. (some col.) ;; 25 cm
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| ISBN
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9780199577170 (alk. paper)
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: 019957717X (alk. paper)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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DNA structure and stability : mutations versus repair -- Regulation of gene expression -- Growth factor signaling and oncogenes -- The cell cycle -- Growth inhibition and tumor suppressor genes -- Apoptosis -- Stem cells and differentiation -- Metastasis -- The immune system, infections, and inflammation -- Nutrients, hormones, and gene interactions -- The cancer industry : drug development, pharmacogenomics, and clinical trial design -- Cancer in the future : focus on cancer vaccines and technology -- Appendix 1: Cell cycle regulation -- Appendix 2: Centers for cancer research -- Glossary
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| Abstract
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Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents
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| Subject
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Cancer-- Molecular aspects
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Cancer cells-- Growth
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Cell proliferation-- Molecular aspects
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Neoplasms-- etiology
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Antineoplastic Agents-- therapeutic use
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Cell Transformation, Neoplastic-- genetics
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Molecular Biology-- methods
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Neoplasms-- genetics
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Neoplasms-- therapy
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| Dewey Classification
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616.99407
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| LC Classification
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RC268.4P425 2012
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| NLM classification
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2013 A-007
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QZ 202
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