| Document Type
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BL
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| Record Number
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629426
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| Doc. No
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dltt
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| Title & Author
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Cyclic-nucleotide phosphodiesterases in the central nervous system : : from biology to drug discovery /\ edited by Nicholas J. Brandon, Anthony R. West
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| Series Statement
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Wiley series in drug discovery and development
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| Page. NO
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1 online resource.
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| ISBN
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1118836308 (electronic bk.)
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: 1118836324 (electronic bk.)
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: 1118836502 (electronic bk.)
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: 1118836537 (electronic bk.)
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: 9781118836309 (electronic bk.)
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: 9781118836323 (electronic bk.)
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: 9781118836507 (electronic bk.)
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: 9781118836538 (electronic bk.)
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9780470566688 (cloth)
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| Bibliographies/Indexes
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Includes bibliographical references
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| Contents
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Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P. P. Bollen, Kris Rutten, Olga A. H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin
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| Subject
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Central nervous system.
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| Subject
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Cyclic nucleotide phosphodiesterases.
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3',5'-Cyclic-AMP Phosphodiesterases-- metabolism.
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3',5'-Cyclic-AMP Phosphodiesterases-- therapeutic use.
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Central Nervous System Diseases-- drug therapy.
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Central Nervous System-- physiology.
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Drug Discovery.
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| Dewey Classification
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612.8/2
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| LC Classification
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QP370
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| NLM classification
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QU 136
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| Added Entry
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Brandon, Nicholas J.
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West, Anthony R.,1970-
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| Added Entry
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Ohio Library and Information Network.
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