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Biophysical methods applied in early discovery of a biotherapeutic : case study of an EGFR-IGF1R bispecific adnectin / Michael L. Doyle, James W. Bryson, Virginie Lafont, Zheng Lin, Paul E. Morin, Lumelle A. Schneeweis, Aaron P. Yamniuk, and Joseph Yanchunas Jr -- X-ray crystallography for biotherapeutics / Glen Spraggon -- Solubility and early assessment of stability for protein therapeutics / Sheng-Jiun Wu, Gary L. Gilliland and Yiqing Feng -- Biophysical and structural characterization needed prior to proof of concept / Angela W. Blake-Haskins, Yen-Huei Lin, Zhuchun Wu, Melissa D. Perkins, Thomas M. Spitznagel -- Nucleation, aggregation, and conformational distortion / Christopher J. Roberts -- Utilization of chemical labeling and mass spectrometry for the biophysical characterization of biopharmaceuticals / Justin B. Sperry and Lisa M. Jones -- Application of biophysical and high throughput methods in the preformulation of therapeutic proteins? : facts and fictions / Ahmad M. Abdul-Fattah and Hanns-Christian Mahler -- Bioanalytical methods and immunogenicity assays / Bonita Rup, Corinna Krinos-Fiorotti, Boris Gorovits, Hendrik Neubert -- Structures and dynamics of proteins probed by UV resonance raman spectroscopy / Brian S. Leigh, Diana E. Schlamadinger, and Judy E. Kim -- Freezing and drying-induced micro-/nanoheterogeneity in biological solutions / Alptekin Aksan, Vishard Ragoonanan, and Carol Hirschmugl -- Late stage product characterization : applications in formulation, process and manufacturing development / Christine P. Chan and Li Shi -- Biophysical analyses suitable for chemistry, manufacturing and control sections of the biological license application (BLA) / Zahra Shahrokh, Nazila Salamat-Miller, John J. Thomas
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