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" Evaluation of enzyme inhibitors in drug discovery : "


Document Type : BL
Record Number : 630011
Doc. No : dltt
Main Entry : Copeland, Robert Allen
Title & Author : Evaluation of enzyme inhibitors in drug discovery : : a guide for medicinal chemists and pharmacologists /\ Robert A. Copeland
Publication Statement : Hoboken, N.J. :: Wiley-Interscience,, 2005
Series Statement : Methods of biochemical analysis ;
Page. NO : xvii, 271 p. :: ill. ;; 25 cm
ISBN : 0471686964 (cloth)
: : 9780471686965 (cloth)
Bibliographies/Indexes : Includes bibliographical references and index
Contents : Why enzymes as drug targets? -- Enzyme reaction mechanisms. -- Reversible modes of inhibitor interactions with enzymes. -- Assay considerations for compound library screening. -- Lead organization and structure-activity relationships for reversible inhibitors. -- Slow binding inhibitors. -- Tight binding inhibitors. -- Irreversible enzyme inactivators. -- Appendix 1. Kinetics if biochemical reactions. -- Appendix 2. Derivation of the enzyme-ligand binding isotherm equation. -- Appendix 3. Serial dilution schemes
Subject : Enzyme inhibitors-- Therapeutic use-- Testing
Subject : Drugs-- Design
Subject : Enzyme inhibitors-- Structure-activity relationships
Subject : Enzyme Inhibitors-- therapeutic use
Subject : Drug Design
Subject : Enzyme Inhibitors-- chemistry
Dewey Classification : ‭615/.19‬
LC Classification : ‭QD271‬‭.M46 v.46‬
NLM classification : ‭W1‬‭ME9617 v.46 2005‬
: ‭QU 143‬‭C782e 2005‬
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