Document Type
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BL
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Record Number
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633445
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Doc. No
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dltt
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Main Entry
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Norman, R. O. C., (Richard Oswald Chandler)
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Title & Author
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Principles of organic synthesis.
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Edition Statement
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3rd ed. // Richard Norman, James M. Coxon.
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Publication Statement
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London ;New York :: Blackie Academic & Professional,, 1993.
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Page. NO
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xv, 811 p. :: ill. ;; 25 cm.
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ISBN
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0751401269 (acid-free)
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: 9780751401264 (acid-free)
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: 0751401951 (ELBS)
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: 9780751401950 (ELBS)
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Notes
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Includes index.
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Bibliographies/Indexes
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Includes bibliographical references and index.
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Contents
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1. Chemical thermodynamics -- 2. Molecular structure -- 3. Chemical kinetics -- 4. Mechanism -- 5. Stereochemistry -- 6. Formation of carbon-carbon bonds: organometallic reagents -- 7. Formation of aliphatic carbon-carbon bonds: base-catalyzed reactions -- 8. Formation of aliphatic carbon-carbon bonds: acid-catalyzed reactions -- 9. Pericyclic reactions -- 10. Formation of aliphatic carbon-nitrogen bonds -- 11. Electrophilic aromatic substitution -- 12. Nucleophilic aromatic substitution -- 13. Aromatic diazonium salts -- 14. Molecular rearrangements -- 15. Reagents containing phosphorus, sulfur, silicon or boron -- 16. Photochemical reactions -- 17. Free-radical reactions -- 18. Organotransition metal reagents -- 19. Oxidation -- 20. Reduction -- 21. The synthesis of five- and six-membered heterocyclic compounds -- 22. The syntheses of some naturally occurring compounds.
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Abstract
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The purpose of this book is to show how mechanistic principles can be applied both to acquiring a knowledge of organic synthetic processes and to planning the construction of organic compounds. It is designed for those who have had no more than a brief introduction to organic chemistry and who require a broad understanding of the subject.
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The book is in two parts. In Part I, reaction mechanism is set in its wider context of the basic principles and concepts that underlie chemical reactions: chemical thermodynamics, structural theory, theories of reaction kinetics, mechanism itself, and stereochemistry.
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In Part II, these principles and concepts are applied to the formation of particular types of bonds, groupings, and compounds: for example, how small molecules can be built on to give larger ones by the construction of new carbon-carbon bonds, or how one functional group can be transformed into another. The final chapter in Part II describes the planning and detailed execution of the multi-step syntheses of several complex naturally occurring compounds.
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There have been numerous important developments since the second edition of this book was published 15 years ago, and every chapter has been brought up to date to include them.
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Among the more notable are: the stereochemical control of reactions, reflecting the need to synthesize efficiently compounds with several asymmetric centres; the use of organotransition-metal reagents, leading to a new chapter; the exploitation of lithium diisopropylamide (LDA) as a base in the formation of new C-C bonds; free-radical reactions for the synthesis of C-C bonds; uses of organosilicon compounds; and subtle new protective and condensing reagents in polypeptide synthesis.
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The text is extensively cross-referenced and a detailed index is included.
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Subject
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Organic compounds-- Synthesis.
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LC Classification
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QD262.N6 1993
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Added Entry
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Coxon, J. M., (James Morriss),1941-
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