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" The molecules of life : "
John Kuriyan, Boyana Konforti, David Wemmer
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BL
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| Record Number
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636492
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dltt
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| Main Entry
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Kuriyan, John
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| Title & Author
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The molecules of life : : physical and chemical principles /\ John Kuriyan, Boyana Konforti, David Wemmer
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| Page. NO
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xxii, 1,008 pages :: color illustrations ;; 28 cm
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| ISBN
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9780815341888
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: 0815341881
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: 9780815341895
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: 081534189X
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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From genes to RNA and proteins -- Nucleic acid structure -- Glycans and lipids -- Protein structure -- Evolutionary variation in proteins -- Energy and intermolecular forces -- Entropy -- Linking energy and entropy : the Boltzmann Distribution -- Free energy -- Chemical potential and the drive to equilibrium -- Voltages and free energy -- Molecular recognition : the thermodynamics of binding -- Specificity of macromolecular recognition --Allostery -- The rates of molecular processes -- Principles of enzyme catalysis -- Diffusion and transport -- Folding -- Fidelity in DNA and protein synthesis
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| Abstract
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This book helps with understanding of how life function by explaining the physical principles underpinning many complex biological phenomena, including how nerves transmit signals, the actions of chaperones in protein folding, and how polymerases and ribosomes achieve high fidelity. The central theme it that the ways in which proteins, DNA, and the RNA work together in a cell are connected intimately to the structures of these biological macromolecules. The structures, in turn, depend on interactions between the atoms in these molecules, and out he interplay between energy and entropy, which results in the remarkable ability of biological systems to self-assemble and control their own replication. By integrating fundamental concepts in thermodynamics at the level of molecular structure, this textbook provides a physical and biochemical foundation for undergraduate students majoring in biology or health sciences
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Molecular biology, Methods
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Genomics, Methods
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Molecular Biology-- methods.
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Biochemical Phenomena-- physiology.
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Genomics-- methods.
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| Dewey Classification
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572/.33
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| LC Classification
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QH506.K875 2013
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| NLM classification
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2012 H-426
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QH 506
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| Added Entry
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Konforti, Boyana
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Wemmer, David
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