| Document Type
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BL
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| Record Number
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640735
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| Doc. No
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dltt
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| Title & Author
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A handbook for DNA-encoded chemistry : : theory and applications for exploring chemical space and drug discovery /\ edited by Robert A. Goodnow, Jr
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| Page. NO
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1 online resource (xxv, 453 pages, 16 unnumbered pages of plates) :: illustrations
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| ISBN
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1118832671 (epub)
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: 1118832698 (electronic bk.)
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: 1118832736 (electronic bk.)
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: 9781118832677 (epub)
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: 9781118832691 (electronic bk.)
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: 9781118832738 (electronic bk.)
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1118832639 ( mobi)
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9781118487686 (cloth)
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9781118832639 ( mobi)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology
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| Abstract
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This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combi
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| Subject
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Combinatorial chemistry-- Technique.
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DNA-- Synthesis.
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Combinatorial Chemistry Techniques-- methods.
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DNA-- chemical synthesis.
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Drug Discovery-- methods.
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Gene Library.
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| Subject
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Small Molecule Libraries-- chemical synthesis.
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| Dewey Classification
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615.1/9
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| LC Classification
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RS420.H36 2014
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| NLM classification
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QV 744
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| Added Entry
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Goodnow, Robert A.,Jr.
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| Added Entry
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Ohio Library and Information Network.
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