|
" Peptidomimetics in organic and medicinal chemistry / "
Dr. Andrea Trabocchi and Professor Antonio Guarna
| Document Type
|
:
|
BL
|
| Record Number
|
:
|
641483
|
| Doc. No
|
:
|
dltt
|
| Main Entry
|
:
|
Trabocchi, Andrea
|
| Title & Author
|
:
|
Peptidomimetics in organic and medicinal chemistry /\ Dr. Andrea Trabocchi and Professor Antonio Guarna
|
| Page. NO
|
:
|
1 online resource
|
| ISBN
|
:
|
111868303X (electronic bk.)
|
|
|
:
|
: 1118683846 (electronic bk.)
|
|
|
:
|
: 9781118683033 (electronic bk.)
|
|
|
:
|
: 9781118683842 (electronic bk.)
|
|
|
:
|
1118683145
|
|
|
:
|
9781118683149
|
|
|
:
|
9781119950608 (hardback)
|
| Bibliographies/Indexes
|
:
|
Includes bibliographical references and index
|
| Abstract
|
:
|
"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"--
|
|
|
:
|
"Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"--
|
| Subject
|
:
|
Drugs-- Design.
|
| Subject
|
:
|
Peptide drugs.
|
| Subject
|
:
|
Proteins-- Therapeutic use.
|
| Dewey Classification
|
:
|
615.1/9
|
| LC Classification
|
:
|
RS431.P38
|
| Added Entry
|
:
|
Guarna, Antonio
|
| Added Entry
|
:
|
Ohio Library and Information Network.
|
| |