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" Fragment-based drug discovery / "
edited by Steven Howard, Chris Abell
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BL
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| Record Number
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648295
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| Doc. No
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dltt
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| Title & Author
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Fragment-based drug discovery /\ edited by Steven Howard, Chris Abell
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| Series Statement
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RSC drug discovery,; 47
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| Page. NO
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xlix, 264 pages :: illustrations (colour) ;; 25 cm
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| ISBN
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9781849739085
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: 1849739080
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9781782620938 (PDF eISBN)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Machine generated contents note: ch. 1 Different Flavours of Fragments / Claudio Dagostin -- 1.1.Fragment-Based Drug Discovery -- 1.2.Different Types of Fragments -- 1.3.How We Identify Fragments -- 1.4.Selectivity -- 1.5.Applications of Fragment-Based Methods -- 1.5.1.Assigning Function -- 1.5.2.Assessing Ligandability -- 1.5.3.Speeding Up Chemical Validation -- 1.6.Targeting Protein -- Protein Interactions and Beyond -- 1.7.Targeting Oligonucleotides -- 1.8.Concluding Remarks -- References -- ch. 2 Getting the Most Value from Your Screens: Advances in Hardware, Software, and Methodologies to Enhance Surface Plasmon Resonance Based Fragment Screening and Hit-to-Lead Support / Brandon J. Bravo -- 2.1.Introduction -- 2.2.SPR Technology as Applied to FBS -- 2.3.The Basic Screening Cascade -- 2.4.Advances in Data Reduction and Active Selection in Primary Screening -- 2.4.1.Robust Drift Correction by Local Estimation -- 2.4.2.Method #1 for Hit Detection: Box Plots --
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| Subject
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Drug development
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Ligands (Biochemistry)
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Drug Discovery
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Ligands
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| Dewey Classification
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615.19
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| LC Classification
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RM301.25.F732 2015
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| NLM classification
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2015 K-133
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QV 745
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| Added Entry
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Howard, Steven,PhD
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Abell, C.
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Royal Society of Chemistry (Great Britain),publisher
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