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" Design and applications of nanoparticles in biomedical imaging / "
Jeff W.M. Bulte, Michel M.J. Modo, editors
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BL
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650042
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dltt
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| Title & Author
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Design and applications of nanoparticles in biomedical imaging /\ Jeff W.M. Bulte, Michel M.J. Modo, editors
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1 online resource (viii, 469 pages)
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9783319421698
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: 3319421697
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9783319421674
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3319421670
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Includes bibliographical references and index
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| Contents
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Preface; Contents; Nanoparticles as a Technology Platform for Biomedical Imaging; 1 Origins of Nanoparticles in Biomedical Imaging; 2 The Emergence of a Synergy Between Therapeutics and Imaging; 3 An Outlook on Challenges and Future Opportunities; References; Basic Principles of In Vivo Distribution, Toxicity, and Degradation of Prospective Inorganic Nanoparticles for Imaging; 1 General Introduction; 1.1 Applying Inorganic Nanoparticles for Imaging; 1.2 Nanoparticles' Fate in a Nutshell; 1.3 The Nanoparticle-Protein Associates
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1.4 Nanoparticle Coating: The Essential But Transient Element in Particle Stabilization and Follow-Up1.5 Cellular "Conditioning" of Administered Nanoparticles and Its Impact on Imaging Outcomes; 1.6 Different Aspects of Biotransformation: Therapeutic Properties, Loss of Functionality, and Potential Toxicity; 1.7 Material-Specific Degradation Patterns of Inorganic Nanoparticles In Vivo and Over Time; 2 Iron Oxide Nanoparticles; 2.1 Role, Effect, and Fate of IONP Synthetic (Polymer) and Biological (Corona) Coating
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2.2 Cell Internalization of IONPs and Its Effects on Nanoparticles' Magnetic Properties2.3 Degradation and Recycling of IONPs; 2.4 In Vivo Toxicity of IONPs; 3 Quantum Dots; 3.1 Cellular Processing and Fate of QDots; 3.2 Skin: The Underemphasized Organ of Nanoparticle's Accumulation; 3.3 In Vivo Toxicity of QDs; 4 Silver Nanoparticles (Ag NPs); 4.1 Therapeutic Properties and In Vivo Behavior of Ag NPs; 4.2 Toxicity of Ag NPs; 5 Gold Nanoparticles (Au NPs); 5.1 Role, Effect, and Fate of Au NPs; 5.2 Cell Internalization of Au NPs
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5.3 Long-Lasting, But Not "Eternal": The In Vivo Biopersistence of Au NPs5.4 In Vivo Toxicity of Au NPs; 6 Conclusion; References; Imaging and Therapeutic Potential of Extracellular Vesicles; 1 Introduction; 2 EV Classification and Biogenesis; 3 EV Production; 4 EV Loading; 4.1 Loading the Parent Cell Before EV Release; 4.2 Loading During EV Production; 4.3 Direct Loading or Decoration of EVs; 5 EV Isolation; 6 Characterization; 7 Engineering Vesicles for Imaging: Biodistribution Investigation; 8 Engineering Vesicles for Therapy and Theranosis; 9 Conclusions; References
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Magnetic Particle Imaging1 Unmet Biomedical Imaging Needs; 2 Introduction to Magnetic Particle Imaging; 2.1 MPI Trade-Offs; 2.2 How MPI Works; 2.3 The Direct Feed-Through Challenge; 2.4 MPI Signal Is Independent of Depth; 2.5 MPI Sensitivity Is Linear, Robust, and Ideal; 2.6 MPI Resolution; 2.7 Prototype Preclinical MPI Scanners; 3 Clinical and Preclinical Applications of Magnetic Particle Imaging; 3.1 Long-Term MPI Tracking of Neural Progenitor Cells; 3.2 Dynamic, Systemic Stem Cell Tracking; 3.3 MPI Angiography Enabled by Advanced Image Reconstruction
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| Abstract
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This book covers the most recent advances in using nanoparticles for biomedical imaging, including magnetic resonance imaging (MRI), magnetic particle imaging (MPI), nuclear medicine, ultrasound (US) imaging, computed tomography (CT), and optical imaging. Topics include nanoparticles for MRI and MPI, siRNA delivery, theranostic nanoparticles for PET imaging of drug delivery, US nanoparticles for imaging drug delivery, inorganic nanoparticles for targeted CT imaging, and quantum dots for optical imaging. This book serves as a valuable resource for the fundamental science of diagnostic nanoparticles and their interactions with biological targets, providing a practical handbook for improved detection of disease and its clinical implementation
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Nanoparticles-- Diagnostic use.
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Diagnostic imaging.
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Nanoparticles.
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Biomedical Engineering.
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| Dewey Classification
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610.28
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| LC Classification
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R857.N34D47 2017
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| NLM classification
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QT 36.5
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Bulte, Jeff W. M.
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Modo, Michel Mathias Jeannot Joseph
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Ohio Library and Information Network.
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