| Document Type
|
:
|
BL
|
| Record Number
|
:
|
652633
|
| Doc. No
|
:
|
dltt
|
| Main Entry
|
:
|
Neidle, Stephen
|
| Title & Author
|
:
|
Therapeutic applications of quadruplex nucleic acids /\ Stephen Neidle
|
| Edition Statement
|
:
|
First edition
|
| Page. NO
|
:
|
xii, 196 pages :: illustrations ;; 24 cm
|
| ISBN
|
:
|
9780123751386 (hbk)
|
|
|
:
|
: 0123751381 (hbk)
|
| Bibliographies/Indexes
|
:
|
Includes bibliographical references and index
|
| Contents
|
:
|
Introduction: quadruplexes and their biology -- DNA and RNA quadruplex structures -- The structures of human telomeric DNA quadruplexes -- Telomeric quadruplex ligands I: anthraquinones and acridines -- Telomeric quadruplex ligands II: polycyclic and non-fused ring compounds -- The biology and pharmacology of telomeric quadruplex ligands -- Genomic quadruplexes as therapeutic targets -- RNA quadruplexes -- Design principles for quadruplex-binding small molecules -- The determination of quadruplex structures
|
| Abstract
|
:
|
"Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. [4] of cover
|
| Subject
|
:
|
Quadruplex nucleic acids-- Therapeutic use
|
| Subject
|
:
|
Antineoplastic Agents-- pharmacology
|
| Subject
|
:
|
Antineoplastic Agents-- therapeutic use
|
| Subject
|
:
|
G-Quadruplexes
|
| Subject
|
:
|
Neoplasms-- drug therapy
|
| Subject
|
:
|
Nucleic Acid Conformation
|
| Subject
|
:
|
Telomere-- chemistry
|
| Dewey Classification
|
:
|
615.36
|
| LC Classification
|
:
|
QP625.Q33N45 2012
|
|
|
:
|
RM666.N87N45 2012
|
| NLM classification
|
:
|
QU 58N397t 2012
|