رکورد قبلیرکورد بعدی

" Genetic manipulation of the nervous system / "


Document Type : BL
Record Number : 653084
Doc. No : dltt
Title & Author : Genetic manipulation of the nervous system /\ edited by D.S. Latchman
Series Statement : Neuroscience perspectives
Page. NO : xvii, 276 pages :: illustrations
ISBN : 9780124371651
: : 0124371655
Bibliographies/Indexes : Includes bibliographical references and index
Contents : Genetic manipulation of the nervous system : an overview / D.S. Latchman -- Non-neurotropic adenovirus : a vector for gene transfer to the brain and possible gene therapy of neurological disorders / P.R. Lowenstein [and others] -- Adenovirus : a new tool to transfer genes into the central nervous system for treatment of neurodegenerative disorders / P. Horrellou, [et al.] -- Adenovirus-mediated gene therapy of tumors in the central nervous system / H.D. Shine and S.L.C. Woo -- Gene delivery using adeno-associated virus / L. Tenenbawn and E.L. Hooghe-Peters -- Herpes simplex virus-based vectors / R.S. Coffin and D.S. Latchman -- Gene delivery using herpes simplex virus type 1 plasmid vectors / K.L. O'Malley and A.I. Geller -- Problems in the use of of herpes simplex virus as a vector / L.T. Feeldman -- Gene delivery to the nervous system by direct injection of retroviral vector / R. Kageyama, M. Ishibashi and K. Moriyoshi -- Gene delivery to the nervous system using retroviral vectors / M. Sena-Esteves, [et al.] -- Transplantation of genetically modified non-neuronal cells in the central nervous system / M.-C. Senut, S.T. Suhr and F.H. Gage -- Genetic animal models for Alzheimer's disease / R.L. Neve, F.M. Boyce and M.L. Oster-Granite -- Neuronal precursors in the brain of adult mammals : biology and applications / C. Lois and A. Alvarez-Buylla -- Direct injection of plasmid DNA into the brain / M. Tsuda ans T. Imaoka -- Antisense oligodeoxynucleotides as novel neuropharmacological tools for selective expression blockade in the brain / M. Helig and K.-H. Schlingensiepen
Abstract : Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. The recent development of Gene Therapy procedures which allow specific genes to be delivered to human patients who lack functional copies of them is of major therapeutic importance. In addition such gene delivery methods can be used in other organisms to define the function of particular genes. These studies are of particular interest in the nervous system where there are many incurable diseases like Alzheimer's and Parkinson's diseases which may benefit from therapies of this kind. Unfortunately gene delivery methods for use in the nervous system have lagged behind those in other systems due to the fact that the methods developed in other systems are often not applicable to cells like neurons which do not divide. This book discusses a wide range of methods which have now been developed to overcome these problems and allow safe and efficient delivery of particular genes to the brain. Methods discussed include virological methods, physical methods (such as liposomes) and the transplantation of genetically modified cells. In a single volume therefore this book provides a complete view of these methods and indicates how they can be applied to the development of therapies for treating previously incurable neurological disorders
Subject : Neurogenetics
Subject : Central Nervous System Diseases-- therapy
Subject : Genetic Therapy-- methods
Subject : Gene Expression Regulation-- genetics
Subject : Genetic Vectors-- therapeutic use
Dewey Classification : ‭616.80442‬
LC Classification : ‭QP356.22‬‭.G46 1996‬
NLM classification : ‭1996 J-902‬
: ‭WL 300‬‭G32627 1996‬
Added Entry : Latchman, David S
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