| Document Type
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BL
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| Record Number
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653312
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| Doc. No
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dltt
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| Main Entry
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Soreq, H
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| Title & Author
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Human cholinesterases and anticholinesterases /\ Hermona Soreq, Haim Zakut
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| Publication Statement
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San Diego :: Academic Press,, c1993
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| Page. NO
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xiv, 314 p. :: ill. ;; 24 cm
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| ISBN
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0126552908 (hardcover)
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| Bibliographies/Indexes
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Includes bibliographical references (p. 247-301) and index
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| Contents
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Biochemical and biological background -- Overview of cholinesterases -- Biochemically defined subsites and their roles in hydrolysis activity -- Anticholinesterases -- Cell type and subcellular localization of cholinesterases -- Molecular polymorphism and its genomic origin -- Putative biological roles of cholinesterases -- Evolutionary divergence and conservation of cholinesterases -- Genetic variants of human cholinesterases -- Cholinesterases and disease states -- Human cholinesterase genes and their expression -- Molecular cloning and expression of human cholinesterase coding sequences -- Promoter elements and alternative splicing in the human acetylcholinesterase gene -- Search for molecular origins of butyrylcholinesterase polymorphism by cDNA screening, deletion mutagenesis, and xenopus oocyte co-injection -- Chromosomal localization of human cholinesterase genes -- Genomic origin of butyrylcholinesterase variants: multiple point mutations in the butyrylcholinesterase -- Structure-function relationships in human butyrylcholinesterase variants
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(cont) Manipulations of butyrylcholinesterase gene expression modulate murine megakaryocytopoiesis in vitro -- In vivo amplification of the human cholinesterase genes -- Scientific and environmental implications -- Human acetylcholinesterase and butyrylcholinesterase genes: comparative analysis -- Expression of recombinant acetylcholinesterase and butyrylcholinesterase in microinjected xenopus oocytes -- Unusual tumor butyrylcholinesterase mRNA transcripts -- In ovo expression of human butyrylcholinesterase muteins reveals structure-function relationships -- Isolation of mutated butyrylcholinesterase sequences from cDNA libraries and their detection in genomic DNA -- Putative involvement of cholinesterases in development -- Modifications in the human cholinesterase genes -- Pollution and ecological implications
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| Subject
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Cholinesterases
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Cholinesterase inhibitors
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Cholinesterase genes
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Cholinergic mechanisms
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Cellular signal transduction
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Cholinesterase Inhibitors-- metabolism
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Cholinesterases-- physiology
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| Dewey Classification
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612/.01925
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| LC Classification
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QP609.C4S67 1993
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| NLM classification
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QU 136 S713h 1993
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| Added Entry
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Zakut, Haim,1935-
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