| Document Type
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BL
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| Record Number
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654433
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| Doc. No
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dltt
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| Title & Author
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Iron chelation therapy /\ edited by Chaim Hershko
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| Series Statement
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Advances in experimental medicine and biology ;; 509
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| Page. NO
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viii, 277 pages :: illustrations ;; 26 cm
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| ISBN
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0306467852
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: 9780306467851
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Pathophysiology of iron overload -- Animal models of hereditary iron transport disorders -- Mechanism of iron toxicity -- Role of non-transferrin-bound iron in the pathogenesis of iron overload and toxicity -- Intacellular and extracellular labile iron pools -- Cardioprotective effect of iron chelators -- Chelation therapy in transfusional siderosis -- Results of long term iron Chelation treatment with deferoxamine -- Long term deferiprone chelation therapy -- Development of new iron chelators -- Iron chelators chemistry -- Structure-activity relationships among desazadesferrithiocin analogues -- ICL670A : preclinical profile -- Pyridoxal isonicotinoyl hydrazone and its analogues -- Novel strategies in iron chelation treatment -- Therapeutic potential of iron chelators in cancer therapy -- Antimalarial effect of iron chelators
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| Abstract
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This book reviews the impact of long-term iron chelating therapy using deferoxamine or the new, but controversial oral iron chelator deferiprone based on experience gained by multicenter trials, with special emphasis on survival, morbidity and drug toxicity; reviews the development of new and improved orally effective chelators that may be suitable for clinical use in the near future; and examines novel strategies of iron chelating treatment for the control of cell proliferation in malignant disease or malaria
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| Subject
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Chelation therapy
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| Subject
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Iron-- Metabolism-- Disorders
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| Subject
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Iron Metabolism Disorders
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| Subject
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Chelation Therapy
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| Dewey Classification
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616.3/96
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| LC Classification
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RC632.I7I75 2002
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| NLM classification
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W1AD559 v.509 2002
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WD 200.5.I7I71 2002
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| Added Entry
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Hershko, Chaim
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