|
" Environmental chemicals, enzyme function, and human disease. "
| Document Type
|
:
|
BL
|
| Record Number
|
:
|
656656
|
| Doc. No
|
:
|
dltt
|
| Main Entry
|
:
|
Symposium on Drug-Metabolizing Enzymes and Environmental Chemicals: Toxic Interactions(1979 :, London, England)
|
| Title & Author
|
:
|
Environmental chemicals, enzyme function, and human disease.
|
| Publication Statement
|
:
|
Amsterdam ;New York :: Excerpta Medica ;New York :: Elsevier/North-Holland,, 1980.
|
| Series Statement
|
:
|
Ciba Foundation symposium ;; 76 (new ser.)
|
| Page. NO
|
:
|
x, 380 p. :: ill. ;; 25 cm.
|
| ISBN
|
:
|
0444901485 (Elsevier/North-Holland)
|
|
|
:
|
: 0444901574 (Elsevier/North-Holland)
|
|
|
:
|
: 9780444901576 (Elsevier/North-Holland)
|
|
|
:
|
: 9021940817
|
|
|
:
|
: 9789021940816
|
|
|
:
|
: 9021940825 (Excerpta Medica)
|
|
|
:
|
: 9789021940823 (Excerpta Medica)
|
| Notes
|
:
|
Proceedings of the Symposium on Drug-Metabolizing Enzymes and Environmental Chemicals: Toxic Interactions, held at Ciba Foundation, London, Oct. 23-25, 1979.
|
|
|
:
|
Editors: David Evered and Geralyn Lawrenson.
|
| Bibliographies/Indexes
|
:
|
Includes bibliographical references and indexes.
|
| Contents
|
:
|
The role of the drug-metabolizing enzymes / James W. Bridges -- The influence of inducers on drug-metabolizing enzyme activity and on formation of reactive drug metabolites in the liver / Sten Orrenius, Hjordis Thor, Bengt Jernstrom -- Effects of inducers and inhibitors on drug-metabolizing enzymes and on drug toxicity in extrahepatic tissues / Michael R. Boyd -- Induction of enzymes involved in DNA repair and mutagenesis / B.A. Bridges -- Induction of drug-metabolizing enzymes by polycyclic aromatic hydrocarbons: mechanisms, and some implications in environmental health research / John R. Bend -- Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects / Urs A. Meyer, Peter J. Meier, Hans Hirsiger, Urs Giger, Felix R. Althaus -- Substrate-dependent irreversible inactivation of cytochrome P-450 : conversion of its haem moiety into modified porphyrins / Francesco De Matteis, Anthony H. Gibbs, Lavinia Cantoni, Jean Francis -- Regulation of human drug metabolism by dietary factors / A.H. Conney, M.K. Buening, E.J. Pantuck, C.B. Pantuck, J.G. Fortner, K.E. Anderson, A. Kappas -- Infiuence of foreign compounds on formation and disposition of reactive metabolites / F. Oesch -- Pharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolites / James R. Gillette -- Toxicological implications of polymorphic drug metabolism / J.C. Ritchie, T.P. Sloan, J.R. Idle, R.L. Smith -- Immunologically mediated toxicity / H.E. Amos -- Toxicological significance of liver hypertrophy produced by inducers of drug-metabolizing enzymes / Emmanuel Farber -- The influence of nutrition and inducers on mechanisms of toxicity in humans and animals / Andre E.M. McLean, David J. Wltts, Denise Tame -- Influence of environmental chemicals on drug therapy in humans : studies with contraceptive steroids / A.M. Breckenridge, D.J. Back, Karen Cross, Francesca Crawford, M. MacIver, M.L'E. Orme, P.H. Rowe, Eileen Smith -- Vitamin D metabolism in patients treated with phenytoin and phenobarbitone / J.O. Hunter, M. Davie -- Chemical disease in humans : problems in comparative toxicology / Irving J. Selikoff -- Implications for future studies in humans / John Higginson.
|
| Subject
|
:
|
Toxicology, Congresses.
|
| Subject
|
:
|
Drugs-- Metabolism, Congresses.
|
| Subject
|
:
|
Enzyme induction, Congresses.
|
| Subject
|
:
|
Biotransformation (Metabolism), Congresses.
|
| Subject
|
:
|
Carcinogens, Environmental, Congresses.
|
| Subject
|
:
|
Pharmaceutical Preparations-- metabolism, Congresses.
|
| Subject
|
:
|
Enzymes-- metabolism, Congresses.
|
| Subject
|
:
|
Neoplasms-- etiology, Congresses.
|
| Dewey Classification
|
:
|
615.9
|
| LC Classification
|
:
|
RA1191.S95 1979
|
| NLM classification
|
:
|
W3C161F v.76 1979
|
| Added Entry
|
:
|
Evered, David.
|
|
|
:
|
Collins, Geralyn M.
|
| Added Entry
|
:
|
Ciba Foundation.
|
| |