| Document Type
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BL
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| Record Number
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656887
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| Doc. No
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dltt
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| Title & Author
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Nuclear receptors in drug metabolism /\ edited by Wen Xie
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| Publication Statement
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Hoboken, NJ :: John Wiley & Sons,, c2009
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| Page. NO
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xxii, 330 p., [8] p. of plates :: ill. (some col.) ;; 25 cm
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| ISBN
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0470086793 (cloth)
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: 9780470086797 (cloth)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Drug metabolism : significance and challenges -- Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors -- Nuclear receptor-mediated regulation of phase II conjugating enzymes -- Nuclear receptor-mediated regulation of drug transporters -- Structure and function of PXR and CAR -- Xenobiotic receptor cofactors and coregulators -- Animal models of xenobiotic nuclear receptors and their utility in drug development -- Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines -- Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics -- Beyond PXR and CAR, regulation of xenobiotic metabolism by other nuclear receptors -- Emerging role of retinoid-related orphan receptor (ROR) and its cross talk with LXR (liver X receptor) in the regulation of drug-metabolizing enzymes
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| Subject
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Drugs-- Metabolism
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| Subject
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Nuclear receptors (Biochemistry)
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Genetic regulation
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Receptors, Cytoplasmic and Nuclear-- metabolism
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Drug Delivery Systems-- methods
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Pharmaceutical Preparations-- metabolism
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Receptors, Steroid-- metabolism
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| Dewey Classification
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615/.7
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| LC Classification
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RM301.55.N83 2009
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RM301.55.N83 2009
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| NLM classification
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QV 38N964 2009
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| Added Entry
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Xie, Wen,1967-
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