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" Physiologically-based pharmacokinetic (PBPK) modeling and simulations : "
Sheila Annie Peters
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BL
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| Record Number
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657274
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| Doc. No
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dltt
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| Main Entry
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Peters, Sheila Annie
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| Title & Author
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Physiologically-based pharmacokinetic (PBPK) modeling and simulations : : principles, methods, and applications in the pharmaceutical industry /\ Sheila Annie Peters
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| Publication Statement
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Hoboken, N.J. :: Wiley,, c2012
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| Page. NO
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xvii, 430 p. :: ill. ;; 24 cm
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| ISBN
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9780470484067 (cloth)
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: 0470484063 (cloth)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Modeling in the pharmaceutical industry -- Physiologically-based modeling -- Review of pharmacokinetic principles -- Physiological model for absorption -- Physiological model for distribution -- Physiological models for drug metabolism and excretion -- Generic whole-body physiologically-based pharmacokinetic modeling -- Variability, uncertainty and sensitivity analysis -- Evaluation of drug-drug interaction risk with PBPK models -- Physiologically-based pharmacokinetics of biotherapeutics -- Data integration and sensitivity analysis -- Hypothesis generation and pharmacokinetic predictions -- Integration of PBPK and pharmacodynamics -- Physiologically-based pharmacokinetic modeling of populations -- PBPK models along the drug discovery and development value chain
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| Subject
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Pharmacokinetics-- Mathematical models
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Drugs-- Design-- Mathematical models
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Pharmacokinetics
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Drug Design
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Models, Biological
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| Dewey Classification
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615/.7
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| LC Classification
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RM301.5.P48 2012
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| NLM classification
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2012 C-941
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QV 38
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| Parallel Title
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Physiologically based pharmacokinetic (PBPK) modeling and simulations
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