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" Polymers in regenerative medicine : "
edited by Manuel Monléon Pradas, Maria J. Vicent
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BL
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657463
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| Title & Author
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Polymers in regenerative medicine : : biomedical applications from nano- to macro-structures /\ edited by Manuel Monléon Pradas, Maria J. Vicent
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1 online resource
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| ISBN
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9781118356685
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: 1118356683
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9781118905814
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1118905814
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9781118356692
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1118356691
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9780470596388
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Includes bibliographical references and index
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| Contents
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Methods for Synthetic Extracellular Matrices and Scaffolds -- Polymers as Materials for Tissue Engineering Scaffolds / Ana Voiles Lluch, Dunia Mercedes García Cruz, Jorge Luis Escobar Ivinco, Cristina Martinez Ramos, Manuel Monleon Pradas -- The Requirements Imposed by Application on Material Structures Intended as Tissue Engineering Scaffolds -- Composition and Function -- General Considerations -- Some Families of Polymers for Tissue Engineering Scaffolds -- Composite Scaffold Matrices -- Structure and Function -- General Considerations -- Structuring Polymer Matrices -- Properties of Scaffolds Relevant for Tissue Engineering Applications -- Porous Architecture -- Solid State Properties: Glass Transition, Crystallinity -- Mechanical and Structural Properties -- Swelling Properties -- Degradation Properties -- Diffusion and Permeation -- Surface Tension and Contact Angle -- Biological Properties -- Compound, Multicomponent Constructs -- Scaffold-Cum-Gel Constructs -- Scaffolds and Membranes Containing Microparticles -- Other Multicomponent Scaffold Constructs -- Questions Arising from Manipulation and Final Use -- Sterilization -- Cell Seeding, Cell Culture, Analysis -- In the Surgeon's Hands, 37 References -- Natural-Based and Stimuli-Responsive Polymers for Tissue Engineering and Regenerative Medicine / Mariana B. Oliveira, Joao F. Mono -- Introduction -- Natural Polymers and Their Application in TE & RM -- Polysaccharides -- Protein-Based Polymers -- Polyesters -- Natural Polymers in Stimuli-Responsive Systems -- pH-Sensitive Natural Polymers -- Temperature Sensitive Natural Polymers -- Natural Polymers Modified to Show Thermoresponsive Behavior-Modifying Responsive Polymers and Agents -- Light-Sensitive Polymers-Potential Use of Azobenzene/u-Cyclodextrin Inclusion Complexes -- Conclusions, 73 References -- Matrix Proteins Interactions with Synthetic Surfaces / Patricia Rico, Marco Cantini, George Altankov, Manuel Salmerdn-Sánchez -- Introduction -- Protein Adsorption -- Cell Adhesion Proteins -- Experimental Techniques to Follow Protein Adsorption -- Effect of Surface Properties on Protein Adsorption -- Cell Adhesion -- Experimental Techniques to Characterize Cell Adhesion -- Cell Adhesion at Cell-Material Interface -- Remodeling of the Adsorbed Proteins -- Protein Reorganization and Secretion at the Cell-Material Interface -- Proteolytic Remodeling at Cell-Materials Interface, 126 References -- Focal Adhesion Kinase in Cell-Material Interactions / Cristina Gonzdlez-García, Manuel Salmeron-Sánchez, Andres J. Garcia -- Introduction -- Role of FAK in Cell Proliferation -- Role of FAK in Migratory and Mechanosensing Responses -- Role of FAK in the Generation of Adhesives Forces -- Influence of Material Surface Properties on FAK Signaling -- Effect of Mechanical Properties on FAK Signaling -- Effect of Surface Topography on FAK Signaling -- Effect of Surface Chemistry on FAK Signaling -- Effect of Surface Functionatization in FAK Expression, 165 References -- Complex Cell-Materials Microenvironments in Bioreactors / Siergios C. Dermenoudis, Yannis F. Missirlis -- Introduction -- Cell-ECM Interactions -- ECM Chemistry -- ECM Topography -- ECM Mechanical Properties -- ECM 3D Structure -- ECM-Induced Mechanical Stimuli -- Cell-Nutrient Medium -- Composition and Volume-Related Phenomena -- Mechanical Stresses Induced by Nutrient Medium -- Other Aspects of Interaction -- Co-Culture Systems -- Material Interactions -- Conclusions, 197 References -- Nanostructures for Tissue Engineering -- Self-Curing Systems for Regenerative Medicine / Julio San Roman, Blanca Vazquez, Maria Rosa Aguilar -- Introduction -- Self-Curing Systems for Hard Tissue Regeneration -- Antimicrobial Self-Curing Formulations -- Self-Curing Formulations for Osteoporotic Bone -- Antineoplastic Drug-Loaded Self-Curing Formulations -- Nonsteroidal Anti-Inflammatory Drug-Loaded Formulations -- Self-Curing Formulations with Biodegradable Components -- Self-Curing Hydrogels for Soft Tissue Regeneration -- Chemically Cross-Linked Hydrogels -- Chemically and Physically Cross-Linked Hydrogels -- Expectative and Future Directions, 226 References -- Self-Assembling Peptides as Synthetic Extracellular Matrices / M.T. Fernandez Muinos, C.E. Semino -- Introduction -- In Vitro Applications -- In Vivo Applications -- References -- Polymer Therapeutics as Nano-Sized Medicines for Tissue Regeneration and Repair / Ana Armindn, Pilar Sepulveda, Maria J. Vicent -- Polymer Therapeutics as Nano-Sized Medicines -- The Concept and Biological Rationale behind Polymer Therapeutics -- Current Status and Future Trends -- Polymer Therapeutics for Tissue Regeneration and Repair -- Ischemia/Reperfusion Injuries -- Wound Healing/Repair -- Musculoskeletal Disorders -- Diseases of the Central Nervous System -- Conclusions and Future Perspectives -- References -- How Regenerative Medicine Can Benefit from Nucleic Acids Delivery Nanocarriers? / Erea Borrajo, Anxo Vidal, Maria J. Alonso, Marcos Garcia-Fuentes -- Introduction -- Learning from Viruses: How to Overcome Cellular Barriers -- Nanotechnology in Gene Delivery -- Lipid Nanocarriers -- Polymeric Nanocarriers -- Inorganic Nanoparticles -- Nanotechnology in Regenerative Medicine -- Bone Regeneration -- Cartilage Regeneration -- Tendon Regeneration -- Myocardium Regeneration -- Neurological Tissue -- Conclusions, 313 References -- Functionalized Mesoporous Materials with Gate-Like Scaffoldings for Controlled Delivery / Elena Aznat, Estela Climent, Laura Mondragon, Felix Sancenón, Ramón Martínez-Máñez -- Introduction -- Mesoporous Silica Materials with Gate-Like Scaffoldings -- Controlled Delivery by pH Changes -- Controlled Delivery Using Redox Reactions -- Controlled Delivery Using Photochemical Reactions -- Controlled Delivery via Temperature Changes -- Controlled Delivery Using Small Molecules -- Controlled Delivery Using Biomolecules -- Concluding Remarks, 360 References -- Where Are We Going? Future Trends and Challenges / Sang Jin Lee, Anthony Atala -- Introduction -- Classification of Biomaterials in Tissue Engineering and Regenerative Medicine -- Naturally Derived Materials -- Biodegradable Synthetic Polymers -- Tissue Matrices -- Basic Principles of Biomaterials in Tissue Engineering -- Development of Smart Biomaterials -- Scaffold Fabrication Technologies -- Injectable Hydrogels -- Electro spinning -- Computer-Aided Scaffold Fabrication -- Functionalization of Tissue-Engineered Biomaterial Scaffolds -- Summary and Future Directions, 381 References
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| Abstract
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"With an interdisciplinary list of subjects and contributors, Polymers in Regenerative Medicine covers the broad range of medical applications for polymers, including scaffolds, self assembling materials, and different types of polymeric nanomedicines. The seasoned authors address fundamentals, theories, tools, techniques, types of polymeric systems and biomaterials and examine such hot topics as nanoconjugates, polymers for tissue repair, and electrospinning technique for tissue engineering. The book provides chemists, researchers, and scientists with an overview of the full therapeutic potential of novel polymeric systems that have only been possible through multidisciplinary research"--Provided by publisher
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Polymers.
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Nanomedicine.
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Regenerative medicine.
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Tissue engineering.
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Nanomedicine-- trends
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Regenerative medicine-- trends
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Tissue engineering-- trends
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| Dewey Classification
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610.28/4
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| LC Classification
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R857.M3
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| NLM classification
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QT 37.5.P7
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| Added Entry
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Monleón Pradas, Manuel
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Vicent, Maria J.
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Ohio Library and Information Network.
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