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" Case studies in modern drug discovery and development / "
edited by Xianhai Huang, Robert G. Aslanian
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BL
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| Record Number
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657471
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| Doc. No
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dltt
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| Title & Author
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Case studies in modern drug discovery and development /\ edited by Xianhai Huang, Robert G. Aslanian
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| Publication Statement
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Hoboken, N.J. :: John Wiley & Sons,, c2012
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| Page. NO
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xviii, 451 p., [8] p. of plates :: ill. (some col.) ;; 26 cm
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| ISBN
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9780470601815 (cloth)
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: 0470601817 (cloth)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Introduction: drug discovery in difficult times / Malcom MacCoss -- Discovery and development of the DPP-4 inhibitor JANUVIA (Sita-gliptin) / Emma R. Parmee ... [et al.] -- Olmesartan medoxomil, an angiotensin II receptor blocker / Hiroaki Yanagisawa, Hiroyuki Koike, and Shini-chiro Miura -- Discovery of heterocyclic phosphonic acids as novel AMP mimics that are potent and selective fructose-1,6-bisphosphatase inhibitors and elicit potent glucose-lowering effects in diabetic animals and humans / Qun Dang and Mark D. Erion -- Setting the paradigm of targeted drugs for the treatment of cancer : Imatinib and Nilotinib, therapies for chronic myelogenous leukemia / Paul W. Manley and Jürg Zimmermann -- Amrubicin, a completely synthetic 9-aminoanthracycline for extensive-disease small-cell lung cancer / Mitsuharu Hanada -- The discovery of dual IGF-1R and IR inhibitor FQIT for the treatment of cancer / Meizhong Jin, Elizabeth Buck, and Mark J. Mulvihill -- Discovery and development of Montelukast (Singulair) / Robert N. Young -- Discovery and development of Maraviroc, a CCR5 antagonist for the treatment of HIV infection / Patrick Dorr, Blanda Stammen, Elna van der Ryst -- Discovery of antimalarial drug Artemisinin and beyond / Weiwei Mao, Yu Zhang, and Ao Zhang -- Discovery and process development of MK-4965, a potent nonnucleoside reverse transcriptase inhibitor / Yong-Li Zhong, Thomas J. Tucker, and Jingjun Yin -- Discovery of Boceprevir and Narlaprevir : the first and second generation of HCV NS3 protease inhibitors / Kevin X. Chen and F. George Njoroge -- The discovery of Samsca (Tolvaptan) : the first oral nonpeptide vasopressin receptor antagonist / Kazumi Kondo and Yoshitaka Yamamura -- SILODOSIN (Urief, Rapaflo, Thrupas, Urorec, Silodix) : a selective à1A adrenoceptor antagonist for the treatment of benign prostatic hyperplasia / Masaki Yoshida ... [et al.] -- Raloxifene : a selective estrogen receptor modulator (SERM) / Jeffrey A. Dodge and Henry U. Bryant
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| Subject
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Drug development, Case studies
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Drugs-- Design, Case studies
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Pharmaceutical chemistry, Case studies
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Drug Discovery
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Drug Evaluation
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| Dewey Classification
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615.19
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| NLM classification
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2012 F-309
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QV 744
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| Added Entry
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Huang, Xianhai
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Aslanian, Robert G
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