|
" Parameters for pesticide QSAR and PBPK/PD models for human risk assessment / "
James B. Knaak, editor, Charles Timchalk, editor, Rogelio Tornero-Velez, editor ; sponsored by the ACS Division of Agrochemicals
| Document Type
|
:
|
BL
|
| Record Number
|
:
|
660362
|
| Doc. No
|
:
|
dltt
|
| Title & Author
|
:
|
Parameters for pesticide QSAR and PBPK/PD models for human risk assessment /\ James B. Knaak, editor, Charles Timchalk, editor, Rogelio Tornero-Velez, editor ; sponsored by the ACS Division of Agrochemicals
|
| Publication Statement
|
:
|
Washington, DC :: American Chemical Society,, c2012
|
| Series Statement
|
:
|
ACS symposium series ;; 1099
|
| Page. NO
|
:
|
xii, 349 p. :: ill., col. pl. ;; 24 cm
|
| ISBN
|
:
|
9780841226456 (alk. paper)
|
|
|
:
|
: 0841226458 (alk. paper)
|
| Bibliographies/Indexes
|
:
|
Includes bibliographical references and indexes
|
| Contents
|
:
|
Parameters for pesticide QSAR and PBPK/PD models to inform human risk assessments -- Chiral chemistry and toxicity assessments for pyrethroid pesticides -- Direct chiral separation of pyrethroid isomers by HPLC with chiral stationary phases -- Biotransformation and enzymes responsible for metabolism of pyrethroids in mammals -- Characterization of potential age-related differences in pyrethroid pharmacokinetics -- 15 factors of percutaneous penetration of pesticides -- Percutaneous absorption of pesticide formulations -- Human metabolic interactions of pesticides : inhibition, induction and activation -- Paraoxonase 1 (PON1) status in risk assessment for organophosphate exposure and pharmacokinetics -- Carboxylesterases : a multifunctional enzyme involved in pesticide and lipid metabolism -- Behavioral changes in adult and young rats as indications of cholinesterase inhibition -- Comparison of esterase sensitivity, metabolic efficiency, and toxicity levels of two organophosphorus insecticides, parathion and chlorpyrifos -- Regional brain dosimetry for the organophosphorus insecticide chlorpyrifos in the preweanling rat -- Pyrethroid actions on sodium channels : isoform and species specificity -- In vitro and in vivo experimental data for development and use of pharmacokinetic models for in vitro to in vivo extrapolation of pyrethroid insecticides -- In silico strategies for modeling stereoselective metabolism of pyrethroids -- Quantitative structure-activity relationships for organophosphate enzyme inhibition -- Computational approaches for developing informative prior distributions for bayesian calibration of PBPK models -- Use of cytochrome P450-specific parameters and human biomarker data to develop a human physiologically based pharmacokinetic/pharmacodynamic model for dermal chlorpyrifos exposure -- Use of in vitro data in PBPK models : an example of in vitro to in vivo extrapolation with carbaryl
|
| Subject
|
:
|
Pesticides-- toxicity, Congresses
|
| Subject
|
:
|
Models, Chemical, Congresses
|
| Subject
|
:
|
Pharmacokinetics, Congresses
|
| Subject
|
:
|
Quantitative Structure-Activity Relationship, Congresses
|
| Subject
|
:
|
Risk Assessment, Congresses
|
| Subject
|
:
|
Chemical models, Congresses
|
| Subject
|
:
|
Pharmacokinetics, Congresses
|
| Subject
|
:
|
Risk assessment, Congresses
|
| Dewey Classification
|
:
|
615.9/02
|
| LC Classification
|
:
|
QD480.P373 2012
|
| NLM classification
|
:
|
WA 240
|
| Added Entry
|
:
|
Knaak, James B
|
|
|
:
|
Timchalk, Charles
|
|
|
:
|
Tornero-Velez, Rogelio
|
| Added Entry
|
:
|
American Chemical Society
|
|
|
:
|
American Chemical Society., Division of Agrochemicals
|
| |