| Document Type
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BL
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| Record Number
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661034
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| Doc. No
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dltt
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| Title & Author
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Immunotoxin methods and protocols\ edited by Walter A. Hall.
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| Publication Statement
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Totowa, N.J. :: Humana Press,, c2001.
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| Series Statement
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Methods in molecular biology ;; v. 166
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| Page. NO
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xi, 302 p. :: ill. ;; 24 cm.
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| ISBN
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0896037754 (alk. paper)
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: 9780896037755 (alk. paper)
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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pt. 1. Immunotoxin construction and development -- Development and activities of the BR96-doxorubicin immunoconjugate -- CD7-specific single chain Fv immunotoxins: design and expresion -- Recombinant fusion toxins directed against the human granulocyte-macrophage colony stimulating factor (GM-CSF) receptor -- Synthesis of monensin derivatives and their effect on the activity of ricin A-chain immuonotoxins -- Purification and conjugation of type 1 ribosome-inactivating proteins -- Comparison of immuotoxins bearing a single saporin molecule with multiple toxin conjugates -- Modulation of growth factor receptor expression by irradiation for immunotoxin targeting -- Quantification of immunotoxin number for complete therapeutic response -- In vitro studies of ricin A-chain-induced vascular leak syndrome -- pt. 2. Oncologic applications of immunotoxins -- Immunotoxin treatment of brain tumors -- Cytotoxins directed at interleukin-4 receptors as therapy for human brain tumors -- Bispecific monoclonal antibiodies for the targeting of type 1 ribosome-inactivating proteins against hematological malignancies -- Tyrosine kinaseinhibitors against EGF receptor-positive malignancies -- Targeting tumor vasculature using VEGF-toxin conjugates -- Gene therapy with immunotoxins -- pt. 3. Alternative applications of immunotoxins -- Effects of selective immunotoxic lesions on learning and memory -- Targeting toxins to neural antigens and receptors -- In vivo testing of anti-HIV immunotoxins.
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| Subject
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Antibody-toxin conjugates.
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| Subject
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Antibody-drug conjugates.
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| Added Entry
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Hall, Walter A.,1957-
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