|
" Biobetters : "
Amy Rosenberg, Barthélemy Demeule, editors
| Document Type
|
:
|
BL
|
| Record Number
|
:
|
668483
|
| Doc. No
|
:
|
dltt
|
| Title & Author
|
:
|
Biobetters : : protein engineering to approach the curative /\ Amy Rosenberg, Barthélemy Demeule, editors
|
| Series Statement
|
:
|
AAPS advances in the pharmaceutical sciences series,; 19
|
| Page. NO
|
:
|
1 online resource (xv, 378 pages) :: color illustrations.
|
| ISBN
|
:
|
1493925431
|
|
|
:
|
: 9781493925438
|
|
|
:
|
1493925423 (print)
|
|
|
:
|
9781493925421
|
|
|
:
|
9781493925421 (print)
|
| Notes
|
:
|
Includes index
|
| Contents
|
:
|
Introduction -- Targeting glucocerebrosidase to macrophages for effective treatment of patients with Gaucher disease: setting the paradigm of a "fit for purpose" approach to enzyme replacement therapy -- Challenges of Enzyme Replacement Therapy: Poor tissue distribution in lysosomal diseases using Pompe disease as a model -- Muscle targeting -- Blood-Brain Barrier Targeting of Therapeutic Lysosomal Enzymes -- Novel Methods for Addressing Immunogenicity in Therapeutic Enzymes -- Structure of monoclonal antibodies -- Prediction of aggregation in vivo by studies of therapeutic proteins in human plasma -- Effect of Hydrolytic Degradation on the In Vivo Properties of Monoclonal Antibodies -- Oxidation of proteins in the in-vivo environment: what we know; what we need to study and potential mitigation strategies -- Molecular assessment: balancing affinity, PK and manufacturability -- Perspectives on engineering biobetter therapeutic proteins with greater stability in inflammatory environments -- Antibody-like molecules designed for superior targeting and pharmacokinetics -- Alternative protein scaffolds as novel biotherapeutics -- Current strategies for pharmacokinetic optimization -- Biosimilar and Biobetter Scenarios for the US and Europe: What Should We Expect? -- Regulatory considerations for approval of biobetter products
|
| Subject
|
:
|
Protein drugs.
|
| Subject
|
:
|
Protein engineering.
|
| Subject
|
:
|
Proteins-- Biotechnology.
|
| Dewey Classification
|
:
|
660.6/3
|
| LC Classification
|
:
|
TP248.65.P76
|
| Added Entry
|
:
|
Demeule, Barthélemy
|
|
|
:
|
Rosenberg, Amy
|
| Added Entry
|
:
|
Ohio Library and Information Network.
|
| |