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" Apoptosis and cancer : "
edited by Gil Mor and Ayesha B. Alvero.
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BL
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| Record Number
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668884
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dltt
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| Title & Author
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Apoptosis and cancer : : methods and protocols /\ edited by Gil Mor and Ayesha B. Alvero.
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| Publication Statement
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Totowa, N.J. :: Humana Press,, ©2008.
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| Series Statement
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Methods in molecular biology (Clifton, N.J.) ;; v. 414
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| Page. NO
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xi, 266 pages :: illustrations.
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| ISBN
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9781588294579
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: 1588294579
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: 9781597453394
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: 1597453390
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Modulation of apoptosis to reverse chemoresistance / Gil Mor, Michele K. Montagna, and Ayesha B. Alvero -- Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis / Suparna Mazumder, Dragos Plesca, and Alexandru Almasan -- Flow cytometry enumeration of apoptotic cancer cells by apoptotic rate / David Diaz [and others] -- Detection of cancer-related proteins in fresh-frozen ovarian cancer samples using laser capture microdissection / Dan-Arin Silasi [and others] -- Flow cytometric detection of activated caspase-3 / Richard Fox and Martine Aubert -- The chemofx® assay : an ex vivo chemosensitivity and resistance assay for predicting patient response to cancer chemotherapy / Stacey L. Brower, Jeffrey E. Fensterer, and Jason E. Bush -- Correlation of caspase activity and in vitro chemo-response in epithelial ovarian cancer cell lines / Ayesha B. Alvero, Michele K. Montagna, and Gil Mor -- Assessing expression of apoptotic markers using large cohort tissue microarrays / Elah Pick, Mary M. McCarthy, and Harriet M. Kluger -- Mitochondria potential, bax "activation," and programmed cell death / C. Michael Knudson and Nicholas M. Brown -- In vitro and in vivo apoptosis detection using membrane permeant fluorescent-labeled inhibitors of caspases / Brian W. Lee [and others] -- Caspase activity assays / Andrew L. Niles, Richard A. Moravec, and Terry L. Riss -- Multiplex caspase activity and cytotoxicity assays / Andrew L. Niles, Richard A. Moravec, and Terry L. Riss -- Homogeneous, bioluminescent proteasome assays / Martha A. O'Brien [and others] -- A simple method for profiling mirna expression / Jia-Wang Wang and Jin Q. Cheng -- Apoptotic caspase activation and activity / Jean-Bernard Denault and Guy S. Salvesen -- Biochemical analysis of the native trail death-inducing signaling complex / Henning Walczak and Tobias L. Haas -- Laser microdissection sample preparation for RNA analyses / Christopher J. Vega.
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| Abstract
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Our understanding of the apoptotic pathway and its regulation has improved significantly in the last 10 years. However, as our knowledge of the intricate intracellular events increase, we realize the complexity of the regulatory mechanisms that control it. As such the text describes the performance of contemporary techniques for studying the biology of apoptosis and its role in cancer. This book is a collaboration between academics- and industry-based scientists. The chapters have the technical development characteristic of an academic environment and the standardized system necessary for translating a product to general use, as provided by the industry. Thus, the protocols described within this volume will aid both an academic laboratory interested in further characterizing the mechanism of apoptosis and an industry laboratory interested on identifying new target molecules or screening for new compounds with potential clinical use. The authors have created a comprehensive te.
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| Subject
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Carcinogenesis.
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Apoptosis.
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Cancer cells.
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Cancer-- Growth-- Regulation.
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Neoplasms-- etiology.
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Neoplasms-- physiopathology.
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Apoptosis-- physiology.
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Caspases.
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| Dewey Classification
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616.99407 22
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| LC Classification
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RC268.5.A6526 2008
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| NLM classification
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W1ME9616J v.414 2008
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QZ 202A6434 2008
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| Added Entry
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Mor, Gil.
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Alvero, Ayesha B.
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