| Document Type
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BL
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| Record Number
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687392
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| Doc. No
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b509581
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| Title & Author
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Checkpoint controls and targets in cancer therapy /\ edited by Zahid H. Siddik.
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| Publication Statement
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Dordrecht ;New York :: Humana Press,, [2010]
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, ©2010
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| Series Statement
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Cancer drug discovery and development
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| Page. NO
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1 online resource (xiv, 273 pages) :: illustrations (some color).
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| ISBN
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1607611783 (e-isbn)
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: 9781607611783 (e-isbn)
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1607611775
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9781607611776
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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1. Circuitry of Checkpoint Response -- Evasion of G1 Checkpoints in Cancer -- Distinct Pathways Involved in S-Phase Checkpoint Control -- Mechanisms of G2 Phase Arrest in DNA Damage-Induced Checkpoint Response -- 2. Checkpoint Response and the Aetiology of Cancer -- Chromatin Modifications and Orchestration of Checkpoint Response in Cancer -- DNA Damage Response and the Balance Between Cell Survival and Cell Death -- Dysfunction of the RB Retinoblastoma Gene in Cancer -- G1 Phase Cyclins in Cancer Development and Progression -- The BRCA1/2 Pathway Prevents Some Leukemias and Lymphomas in Addition to Breast/Ovarian Cancers: Malignancies that Overcome Checkpoint Controls -- 3. Targeting Checkpoint Response in Cancer Therapy -- Regulation of p53 Activity and Associated Checkpoint Controls -- The Importance of p53 Signaling in the Response of Cells to Checkpoint Inhibitors -- Targeting p21-Dependent Pathways for Cell Death in Cancer Therapy -- p27Kip1 as a Biomarker and Target for Treatment of Cancer -- Targeting Cyclin-Dependent Kinases with Small Molecule Inhibitors -- Chk1 and Chk2 as Checkpoint Targets -- Targeting Cdc25 Phosphatases in Cancer Therapy
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| Subject
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Antineoplastic agents-- Development.
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Cancer cells-- Growth-- Regulation.
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Cellular control mechanisms.
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Neoplasms-- drug therapy.
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Antineoplastic Agents-- pharmacology.
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Cell Cycle Proteins-- drug effects.
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Cell Cycle-- drug effects.
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| Subject
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Drug Resistance, Neoplasm.
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| Dewey Classification
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571.84377
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| LC Classification
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QP552.G76C44 2010eb
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| Added Entry
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Siddik, Zahid H.
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| Added Entry
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Ohio Library and Information Network.
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