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" Molecular mechanisms of adult stem cell aging / "
volume editor, Karl Lenhard Rudolph
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BL
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| Record Number
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690296
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b512485
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| Main Entry
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Else Kröner-Fresenius Symposium on the Molecular Mechanisms of Adult Stem Cell Aging(1st :2009 :, Günzburg, Germany)
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| Title & Author
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Molecular mechanisms of adult stem cell aging /\ volume editor, Karl Lenhard Rudolph
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| Publication Statement
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Basel :: Karger,, c2010
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| Series Statement
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Else Kröner-Fresenius symposia,; v. 1
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| Page. NO
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viii, 107 p. :: ill. (chiefly col.) ;; 26 cm
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| ISBN
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3805592434 (hard cover : alk. paper)
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: 3805592442 (eISBN)
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: 9783805592437 (hard cover : alk. paper)
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: 9783805592444 (eISBN)
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| Notes
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Papers from the first Else Kröner-Fresenius Symposium on the Molecular Mechanisms of Adult Stem Cell Aging, held in Günzburg, Germany in May 2009
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Speakers at the Symposium / Hartmann, D. -- Hematopoietic stem cell aging and fate decision / Illing, A., Ju, Z. -- Alterations of systemic environment impair stem cell function during aging / Song, Z., Ju, Z. -- Novel insights into regulation of stem cell aging by aging of the niche and alterations in systemic factors / Geiger, H. -- Aging and hematopoietic malignancies / Gompf, A. -- Intestinal stem cell aging / Sperka, T., Rudolph, K.L. -- Molecular mechanisms of aging in muscle stem cells / Tümpel, S. -- Free radicals and stem cell aging / Guachalla, L.M. -- DNA damage, checkpoint responses, and cell cycle control in aging stem cells / Sperka, T., Nalapareddy, K., Rudolph, K.L
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| Abstract
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"There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field. The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and regenerative potential during aging and during the end stage of chronic diseases. In addition, it can contribute to stem cell transformation and carcinogenesis. Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. It is also likely to be an invaluable resource for medical students and biologists who wish to enhance their understanding of molecular and stem cell biology."--Publisher's description
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| Subject
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Aging-- Molecular aspects, Congresses
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Cells-- Aging, Congresses
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Stem cells, Congresses
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Adult Stem Cells-- physiology, Congresses
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Cell Aging-- genetics, Congresses
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DNA Damage-- physiology, Congresses
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Telomere-- genetics, Congresses
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| Dewey Classification
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616/.02774
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| LC Classification
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QH588.S83E447 2009
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| NLM classification
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2010 F-608
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QU 325E49m 2010
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| Added Entry
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Rudolph, K. Lenhard
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