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" DNA topoisomerases and cancer / "
Yves Pommier, editor.
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BL
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| Record Number
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696488
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b518677
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| Title & Author
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DNA topoisomerases and cancer /\ Yves Pommier, editor.
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| Publication Statement
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New York :: Springer,, [2012]
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, ©2012
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| Series Statement
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Cancer drug discovery and development
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| Page. NO
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1 online resource (xi, 443 pages) :: illustrations (some color).
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| ISBN
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1461403235 (electronic bk.)
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: 9781461403234 (electronic bk.)
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1461403227
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9781461403227
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Introduction and historical perspective / Patrick Forterre -- Human DNA topoisomerase I : structure, enzymology and biology / James J. Champoux -- Mitochondrial topoisomerases / Ilaria Dalla Rosa, Yves Pommier, and Hongliang Zhang -- Structure and mechanism of eukaryotic type IIA topoisomerases / James M. Berger and Neil Osheroff -- Essential functions of topoisomerase III-alpha in the nucleus and mitochondria / Stefanie Hartman Chen, Jianhong Wu, and Tao-shih Hsieh -- DNA topoisomerase I and illegitimate recombination / Céline Auzanneau and Philippe Pourquier -- Topoisomerase-induced DNA damage / Yves Pommier and Neil Osheroff -- Topoisomerases and carcinogenesis : topoisomerases III-alpha and BLM / Mounira Amor-Guéret and Jean-François Riou -- Topoisomerases inhibitors : a paradigm for interfacial inhibition / Christophe Marchand and Yves Pommier -- Topoisomerases I inhibitors : chemical biology / Beverly A. Teicher -- Topoisomerases II inhibitors : chemical biology / Anna Rogojina ... [et al.] -- Topoisomerases I inhibitors : current use and prospects / Yan Makeyev ... [et al.] -- Topoisomerases II inhibitors : current use and prospects / Olivier Mir ... [et al.] -- Transcriptional stress by camptothecin : mechanisms and implications for the drug antitumor activity / Giovanni Capranico ... [et al.] -- Mechanisms regulating cellular responses to DNA topoisomerases I-targeted agents / Piero Benedetti and Mary-Ann Bjornsti -- Tyrosyl-DNA-phosphodiesterase / Thomas S. Dexheimer ... [et al.] -- Ubiquitin and ubiquitin-like proteins in repair of topoisomerases-mediated DNA damage / Shyamal D. Desai -- Repair of topoisomerases II-mediated DNA damage : fixing DNA damage arising from a protein covalently trapped on DNA / John L. Nitiss ... [et al.] -- Topoisomerases and apoptosis / Olivier Sordet and Stéphanie Solier
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| Subject
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Cancer-- Chemotherapy.
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| Subject
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DNA topoisomerases-- Inhibitors.
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| Dewey Classification
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572/.786
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| LC Classification
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QP616.D56D53 2012eb
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| Added Entry
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Pommier, Yves.
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| Added Entry
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Ohio Library and Information Network.
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