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" Cancer metastasis : "
edited by David Lyden, Danny R. Welch, Bethan Psaila
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BL
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| Record Number
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705703
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| Doc. No
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b527892
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| Title & Author
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Cancer metastasis : : biologic basis and therapeutics /\ edited by David Lyden, Danny R. Welch, Bethan Psaila
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| Publication Statement
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New York, NY :: Cambridge University Press,, 2011, ©2011
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| Page. NO
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xvii, 642 pages :: illustrations (some color) ;; 29 cm
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| ISBN
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0521887216 (hardback)
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: 9780521887212 (hardback)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Overview: biology is the foundation of therapy / Isaiah J. Fidler; Part I. Basic Research: Introduction to basic research / Harold L. Moses. Models and Tools for Metastasis Studies -- 1. Animal models of cancer metastasis / Janet E. Price -- 2. Drosophilia and zebrafish: genetic models for cancer metastasis / Elisa C. Woodhouse and Kathleen Kelly -- 3. Computational models / Wayne S. Kendal -- 4. Intravital microscopy to visualize invasion and metastasis / Cristina Hidalgo-Carcedo and Erik Sahai. Genes: 5. Metastasis-promoting genes / Devanand Sarkar and Paul B. Fisher -- 6. The role of metastasis suppressor genes in metastasis / Brunilde Gril ... [et al.] -- 7. Stromal-derived factors that dictate organ-specific metastasis / Bedrich L. Eckhardt ... [et al.] -- 8. Metastasis genes: epigenetics / Amaia Lujambio and Manel Esteller -- 9. Germline variation and other host determinants of metastatic potential / Nigel P. S. Crawford and Kent W. Hunter -- 10. The influence of aging and cellular senescence on metastasis / Futoshi Okada and Hiroshi Kobayashi. Various Properties of Cancer Cells: 11. The continuum of epithelial mesenchymal transition - implication of hybrid states for migration and survival in development and cancer / Lilian Soon ... [et al.} -- 12. Apoptosis, anoikis, and senescence / Wen Liu and Kounosuke Watabe -- 13. Metastatic inefficiency and tumor dormancy / Ann F. Chambers. Stromal cells / Extracellular Matrix: 14. Role of inflammation in metastatic progression / Sunhwa Kim and Michael Karin -- 15. Proteolytic cascades in invasion and metastasis / Steven D. Mason and Johanna A. Joyce -- 16. Role of matrix metalloproteinases in tumor invasion and metastasis / Barbara Fingleton -- 17. Cell-derived microvesicles and metastasis / Hector Peinado, Bethan Psaila and David Lyden. Systemic Factors:
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18. Exploring the earliest steps in metastasis: the pre-metastatic niche / Mariannna Papaspyridonos, David Lyden and Rosandra N. Kaplan -- 19. Growth regulatory pathways contributing to organ selectivity of metastasis / Suzanne A. Eccles -- 20. Determinants of organ-specific metastasis / Yibin Kang -- 21. Function and expression of the uPA/uPAR system in cancer metastasis / Julio A. Aguirre-Ghiso, Daniel F. Alonso and Eduardo F. Farias -- 22. The lymphatics: on the route to cancer metastasis / Tara Karnezis ... [et al.]. Part II. Clinical Research. 23. Introduction to clinical research / Nancy E. Davidson -- 24. Sarcoma / Chand Khanna and Lee Helman -- 25. Neuroblastoma / Nai-Kong Cheung and Brian H. Kushner -- 26. Retinoblastoma / Ira J. Dunkel and David H. Abramson -- 27. Primary brain tumors and cerebral metastases / Matthew C. Tate and Mitchel S. Berger -- 28. Head and neck cancer metastasis / Sarbani Ghosh-Laskar ... [et al.] -- 29. Cutaneous melanoma: therapeutic approaches for metastatic disease / Ahmad A. Tarhini and John R. Kirkwood -- 30. Gastric cancer metastasis / Takako Eguchi Nakajima and Yasuhide Yamada -- 31. Metastatic pancreatic cancer / Jose Eduardo M. Cunha, Marcos V. Perini, and Daniela Freitas -- 32. Metastasis of primary liver cancer / Zhao-You Tang and Lun-Xiu Qin -- 33. Advances in management of metastatic colorectal cancer / Andrea Wang-Gillam, A. Craig Lockhart and Joel Picus -- 34. Lung cancer metastasis / Rafael Rosell, Miquel Taron and David Jablons -- 35. Metastatic thyroid cancer: evaluation and treatment / R. Michael Tuttle -- 36. Metastatic renal cell carcinoma / Jean-Jacques Patard, Stephane Culine, and Alaine Ravaud -- 37. Bladder cancer / Naveen Said and Dan Theodorescu -- 38. Bone complications of myeloma and lymphoma / G. David Roodman -- 39. Breast metastasis / Patrick G. Morris, Heather L. McArthur, and Clifford A. Hudis -- 40. Gynecologic malignancies / Sarah M. Temkin and S. Diane Yamada -- 41. Prostate cancer metastasis: thoughts on biology and therapeutics / Kosuke Mizutani, Russell S. Taichman and Kenneth J. Pienta -- 42. The biology and treatment of metastatic testicular cancer / M. Houman Fekrazad, Robert Hromas, Richard Lauer -- 43. Applications of proteomics to metastasis diagnosis and individualized therapy / Mariaelena Pierobon ... [et al.] -- 44. Critical issues of research on circulating and disseminated tumor cells in cancer patients / Klaus Pantel ... [et al.] -- 45. Lymphatic mapping and sentinel lymph node biopsy / Robert H. I. Andtbacka and Jeffrey E. Gershenwald -- 46. Molecular imaging and metastasis / Yufang Hu ... [et al.] -- 47. Preserving bone health in malignancy and complications of bone metastases / Robert E. Coleman -- 48. Role of platelets and thrombin in metastasis / Boris Kobrinsky, Simon Karpatkin and David L. Green. Therapies: 49. Cancer nanotechnology offers great promise for cancer research and therapy / Randy L. Scherer ... [et al.] -- 50. Metronomic chemotherapy for treatment of metastatic disease: from preclinical research to clinical trials / William Cruz-Munoz, Guilio Francia, and Robert S. Kerbel -- 51. Immunotherapy / Pier-Luigi Lollini, Carla De Giovanni, Patrizia Nanni -- 52. Discovery and development of drugs targeting tumor invasion and metastasis / Rob J. Jones, Tim P. Green and Paul Elvin -- 53. The role of radiotherapy in the treatment of metastatic disease / John H. Heinzerling, Jaeho Cho, Hak Choy -- 54. Prospects for clinical trials of metastasis inhibitors / George W. Sledge, Jr
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| Abstract
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"Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed"--Provided by publisher
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| Subject
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Metastasis
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| Subject
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Neoplasm Metastasis-- physiopathology
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| Subject
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Neoplasm Metastasis-- therapy
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| Dewey Classification
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616.99/4
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| LC Classification
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RC269.5.C355 2011
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| NLM classification
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2011 F-662
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QZ 202
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| Added Entry
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Lyden, David,1959-
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Psaila, Bethan,1979-
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Welch, Danny R.,1958-
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