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" Translational medicine and drug discovery / "
edited by Bruce H. Littman, Rajesh Krishna
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BL
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| Record Number
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705705
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b527894
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| Title & Author
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Translational medicine and drug discovery /\ edited by Bruce H. Littman, Rajesh Krishna
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| Publication Statement
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New York :: Cambridge University Press,, 2011
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| Page. NO
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xx, 361 p. :: ill. ;; 26 cm
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| ISBN
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0521886457 (hardback)
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: 9780521886451 (hardback)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Section I. Translational medicine: history, principles and application in drug development: 1. Translational medicine:definition, history, and strategies/ Bruce H. Littman -- 2. Translational medicine and its impact on diabetes drug development / Roberto A. Calle and Ann E. Taylor -- 3. Challenges in atherosclerosis / John S. Millar -- 4. Obesity: new mechanisms and translational paradigms / Gregory Gaich and David E. Moller -- 5. Bone disorders: translational medicine case studies / S. Aubrey Stoch -- 6. Case studies in neuroscience: unique challenges and examples / Gerard J. Marek -- 7. Translational medicine in oncology / Dominic G. Spinella; Section II. Biomarkers and public-private partnerships: 8. Biomarker validation and application in early drug development: idea to proof of concept/ Pfizer Global Research and Development, 2004 -- 9. Image biomarkers in drug development: case studies / Johannes T. Tauscher and Adam J. Schwarz -- 10. European new safe and innovative medicine initiatives: history and progress (through December 2009) / Ole J. Bjerrum and Hans H. Linden -- 11. Critical path institute and the predictive safety testing consortium / Elizabeth Gribble Walker -- 12. The biomarker consortium: facilitating the development and qualification of novel biomarkers through a precompetitive public-private partnership / David Wholley and David B. Lee; Section III. Future Directions: 13. Improving the quality and productivity of pharmacometric modeling and simulation activities: the foundation for model-based drug development / Thaddeus H. Grasela, Jill Fiedler-Kelly, and Robert Slusser -- 14. Embracing change: a pharmaceutical industry guide to the 21st century / Mervyn Turner
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| Abstract
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"Focuses on the new discipline of translational medicine as it pertains to drug development within the pharmaceutical and biotechnology industry"--Provided by publisher
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| Subject
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Drug development
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Molecular pharmacology
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Drug Discovery
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Translational Medical Research-- methods
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| Dewey Classification
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615/.19
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| LC Classification
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RM301.25.T73 2011
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| NLM classification
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2011 C-829
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QV 744T772 2011
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| Added Entry
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Krishna, Rajesh
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Littman, Bruce H.,1944-
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