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" Anticancer drug development / "
edited by Bruce C. Baguley, David J. Kerr
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BL
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| Record Number
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713068
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| Doc. No
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b535257
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| Title & Author
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Anticancer drug development /\ edited by Bruce C. Baguley, David J. Kerr
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| Publication Statement
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San Diego, Calif :: Academic Press,, c2002
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| Page. NO
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xiii, 397 p. :: ill. (some col.) ;; 29 cm
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| ISBN
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0120726513 (alk. paper)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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A brief history of cancer chemotherapy -- Novel targets in the cell cycle and cell cycle checkpoints -- Growth factor and signal transduction targets for cancer therapy -- Cell death pathways as targets for anticancer drugs -- Drug resistance pathways as targets -- Role of matrix metalloproteinases and plasminogen activators in cancer invasion and metastasis: therapeutic strategies -- Tumor vasculature as a target -- Gene-directed enzyme prodrug therapy -- Tumor antigens as targets for anticancer drug development -- Structure-based drug design and its contributions to cancer chemotherapy -- The contribution of synthetic organic chemistry to anticancer drug development -- Biosynthetic products for anticancer drug design and treatment: the bryostatins -- DNA-encoded peptide libraries and drug discovery -- Mechanism-based high-throughput screening for novel anticancer drug discovery -- Tumor cell cultures in drug development -- Screening using animal systems -- Relevance of preclinical pharmacology and toxicology to Phase I trial extrapolation techniques: relevance of animal toxicity -- Clinical trial design: incorporation of pharmacokinetic, pharmacodynamic, and pharmacogenetic principle -- Tumor imaging applications in the testing of new drugs -- Mechanistic approaches to Phase I clinical trials
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| Subject
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Antineoplastic agents
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Cancer-- Chemotherapy
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Drugs-- Design
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Antineoplastic Agents
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Drug Design
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Drug Evaluation, Preclinical
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| Dewey Classification
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616.994061
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| NLM classification
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2002 B-638
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QV 269A629515 2002
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| Added Entry
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Baguley, Bruce C
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Kerr, David J
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