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" Inhibition of Folate Metabolism in Chemotherapy : "
edited by George H. Hitchings.
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BL
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| Record Number
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715718
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b537872
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| Main Entry
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edited by George H. Hitchings.
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| Title & Author
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Inhibition of Folate Metabolism in Chemotherapy : : the Origins and Uses of Co-trimoxazole\ edited by George H. Hitchings.
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| Publication Statement
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Berlin, Heidelberg: Springer Berlin Heidelberg, 1983
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| Series Statement
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Handbook of Experimental Pharmacology, Continuation of Handbuch der experimentellen Pharmakologie,, 64.
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| ISBN
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3642818900
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: 3642818927
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: 9783642818905
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: 9783642818929
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| Contents
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Trimethoprim/Sulfamethoxazole: An Overview --;A. Introduction --;B. Mechanisms of Action --;C. Resistance --;D. Clinical Use of TMP/SMX --;E. Use of TMP or SMX as Single Agents --;F. Adverse Effects --;G. Summary --;References --;Pharmacology and Biochemistry --;1 Functions of Tetrahydrofolate and the Role of Dihydrofolate Reductase in Cellular Metabolism --;2 Sulfonamides: Structure-Activity Relationships and Mechanism of Action --;3 Dihydrofolate Reductase --;4 Antibacterial Activity --;5 Selective Inhibitors of Bacterial Dihydrofolate Reductase: Structure-Activity Relationships --;6 Kinetics of Antibacterial Effects --;7 Disposition and Metabolism of Trimethoprim, Tetroxoprim, Sulfamethoxazole, and Sulfadiazine --;8 Preclinical Toxicity Testing of Co-trimoxazole and Other Trimethoprim/ Sulfonamide Combinations --;Clinical Pharmacology --;9 Adverse Effect of Co-trimoxazole --;10 Clinical Pharmacokinetics of Co-trimoxazole --;11 Resistance: Genetics and Medical Implications --;Clinical Studies --;12 Trimethoprim Alone: Clinical Uses --;13 Inhibitors of Dihydrofolate Reductase as Antiprotozoal Agents --;14 Pediatric Uses of Sulfonamides, Trimethoprim, and the Combination --;15 Use of Co-trimoxazole in Urinary Tract Infection --;16 Treatment of Genital Infections with Trimethoprim, Sulfonamides, and Combinations --;17 Treatment of Enteric Infections and Combinations --;18 Prostatitis --;19 Co-trimoxazole in Chest Infections Including its Long-Term Use in Chest Disease --;20 Treatment of Miscellaneous and Unusual Infections with Trimethoprim and Trimethoprim/Sulfonamide Combinations.
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| Abstract
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With contributions by numerous experts
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Medicine.
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Pharmacy.
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Toxicology.
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George H Hitchings
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With contributions by numerous experts
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