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Symposium on Depression, antidepressants and receptor sensitivity, held at the Ciba Foundation, London, 19 21 November 1985. Editors: Ruth Porter, Gregory Bock (Organizer) and Sarah Clark. D. Murphy Introduction. S.Z. Langer, A.M. Galzin, C.R. Lee and H. Schoemaker Antidepressant-binding sites in brain and platelets. Discussion. W.H. Berrettini, J. Bardakjian, A.L. Barnett Jr, J.I. Nurnberger Jr and E.S. Gershon beta-Adrenoceptor function in human adult skin fibroblasts: a study of manic-depressive illness. Discussion. P. Propping, W. Friedl, J. Hebebrand and K-U. Lentes Genetic studies at the receptor level: investigations in human twins and experimental animals. Discussion. M. Asberg and A. Wagner Biochemical effects of antidepressant treatment - studies of monoamine metabolites in cerebrospinal fluid and platelet [3H]imipramine binding. Discussion. R.W. Horton, C.L.E. Katona, A.E. Theodorou, A.S. Hale, S.L. Davies, C. Tunnicliffe, Y. Yamaguchi, E.S. Paykel and J.S. Kelly Platelet radioligand binding and neuroendocrine challenge tests in depression. Discussion. D.L. Murphy, C.S. Aulakh and N. A. Garrick How antidepressants work: cautionary conclusions based on clinical and laboratory studies of the longer-term consequences of monoamine oxidase-inhibiting antidepressants. Discussion. S.A. Checkley, T.H. Corn, I.B. Glass, C. Thompson, C. Franey and J. Arendt Neuroendocrine and other studies of the mechanism of antidepressant action of desipramine. Discussion. L.J. Siever, E.F. Coccaro, E. Benjamin, K. Rubinstein and K.L. Davis Adrenergic and serotonergic receptor responsiveness in depression. Discussion. General discussion I. A. Frazer, G. Ordway, J. O'Donnell, P. Vos and B. Wolfe Effect of repeated administration of clenbuterol on the regulation of beta-adrenoceptors in the central nervous system of the rat. Discussion. J.M. Weiss and P.G. Simson Depression in an animal model: focus on the locus ceruleus. Discussion. G.W. Kraemer Causes of changes in brain noradrenaline systems and later effects on responses to social stressors in rhesus monkeys: the cascade hypothesis. Discussion. J. Vetulani, L. Antkiewicz-Michaluk, A. Rokosz-Pelc and J. Michaluk Effects of chronically administered antidepressants and electroconvulsive treatment on cerebral neurotransmitter receptors in rodents with model depression'. Discussion. A.R. Green, D.J. Heal and G.M. Goodwin The effects of electroconvulsive therapy and antidepressant drugs on monoamine receptors in rodent brain - similarities and differences. Discussion. General discussion II. Closing remarks. Index of contributors. Subject index
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