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" Antimicrobial peptides : "
edited by Guangshun Wang.
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BL
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| Record Number
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723375
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b543089
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| Main Entry
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edited by Guangshun Wang.
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| Title & Author
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Antimicrobial peptides : : discovery, design and novel therapeutic strategies\ edited by Guangshun Wang.
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| Edition Statement
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18th ed
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| Publication Statement
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Wallingford, Oxfordshire, UK ; Cambridge, MA: CABI, ©2010.
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| Series Statement
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Advances in molecular and cellular microbiology, 18.
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| Page. NO
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(xvii, 230 pages) : illustrations.
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| ISBN
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1845936949
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: 9781845936945
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| Contents
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A database view of naturally occurring antimicrobial peptides : nomenclature, classification, and amino acid sequence analysis / Guangshun Wang, Xia Li, and Michael Zasloff --;Lantibiotic-related research and the application thereof / Brian Healy [and others] --;Antimicrobial peptides in plants / Quentin Kaas [and others] --;Database-aided prediction and design of novel antimicrobial peptides / Guangshun Wang --;Discovery of novel antimicrobial peptides using combinatorial chemistry and high-throughput screening / William C. Wimley --;Chemical mimics with systemic efficacy / Amram Mor --;Biophysical analysis of membrane-targeting antimicrobial peptides : membrane properties and the design of peptides specifically targeting gram-negative bacteria / Richard M. Epand and Raquel F. Epand --;Non-membrane targets of antimicrobial peptides : novel therapeutic opportunities? / Ju Hyun Cho and Sun Chang Kim --;Structural studies of antimicrobial peptides provide insight into their mechanisms of action / Guangshun Wang --;Lung infection : shifting the equilibrium toward the free and active form of human LL-37 and the design of alternative antimicrobial agents / Paul A. Janmey and Robert Bucki --;Role of vitamin D in the enhancement of antimicrobial peptide gene expression / John White and Ari J. Bitton --;Fine tuning host responses in the face of infection : emerging roles and clinical applications of host defence peptides / Matthew L. Mayer, Donna M. Easton, and Robert E.W. Hancock.
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| Abstract
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The purpose of this book is to provide a comprehensive account on current antimicrobial peptide research in two major directions. The first direction delineates the classic path for peptide development, ranging through identification, design, structure and mode of action studies. The second direction describes novel strategies for developing peptide therapeutics based on our knowledge of host defence antimicrobial peptides discovered in living organisms. Part I provides an overview of nomenclature, classification and bioinformatic analysis of antimicrobial peptides from bacteria, plants and animals. Subsequently, lantibiotics from bacteria and cyclotides from plants are presented. Part II discusses database-aided peptide prediction and design methods, synthetic combinatorial libraries and peptide mimetics that expand the conformational space of natural antimicrobial peptides. Part III covers the biophysical and structural characterization of antimicrobial peptides and their complexes. Finally, Part IV focuses on novel strategies for developing peptide-based therapies.
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| Subject
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Drug Discovery.
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Peptide antibiotics.
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Pharmaceutical chemistry.
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| LC Classification
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RS431.P37E358 2010
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C.A.B. International.
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G Wang
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Guangshun Wang
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| Parallel Title
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Advances in Molecular and Cellular Microbiology 18
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