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" The IGF system : "
edited by Ron G. Rosenfeld, Charles T. Roberts, Jr.
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BL
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| Record Number
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723853
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b543569
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| Main Entry
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edited by Ron G. Rosenfeld, Charles T. Roberts, Jr.
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| Title & Author
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The IGF system : : molecular biology, physiology, and clinical applications\ edited by Ron G. Rosenfeld, Charles T. Roberts, Jr.
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| Publication Statement
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Totowa, N.J.: Humana Press, ©1999.
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| Series Statement
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Contemporary endocrinology (Totowa, N.J.)
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| Page. NO
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(xii, 787 pages) : illustrations
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| ISBN
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1592597122
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: 1617371386
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: 9781592597123
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: 9781617371387
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| Contents
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1 Historical Perspective: The Origins and Development of the Somatomedin Hypothesis --;I Molecular Biology of the IGF System --;2 Molecular Biology of IGF-I and IGF-II --;3 Regulation of IGF Gene Expression --;4 Molecular Biology of the Type 1 IGF Receptor --;5 Molecular Biology of the IGF-II/Mannose-6-Phosphate Receptor --;6 Molecular Biology of the IGF Binding Proteins --;II Biological Actions of the IGFs --;7 IGF-I Receptor Function: Transducing the IGF-I Signal into Intracellular Events --;8 Type 2 IGF Receptor-Mediated Events --;9 Alternative IGF-Related Receptors --;10 IGF Binding Proteins as Modulators of IGF Action --;11 IGF-Independent Actions of the IGF Binding Proteins --;12 IGF Binding Proteins and Extracellular Matrix --;13 Biological Actions of Proteolytic Fragments of the IGF Binding Proteins --;14 The IGF Binding Protein Superfamily --;15 IGFs and Cell Growth --;16 Posttranslational Modification of the IGF Binding Proteins --;III IGF Physiology --;17 IGFs in the Female Reproductive System --;18 The IGF Axis in the Male Reproductive System --;19 IGFs and the Nervous System --;20 IGF System Components and Their Role in Bone Metabolism --;21 IGFs and Skeletal Muscle --;22 IGFs and the Digestive Tract --;23 Actions of IGF System Proteins from Studies of Transgenic and Gene Knockout Models --;IV Clinical Aspects of the IGFs --;24 Metabolic Effects of IGFs --;25 Clinical Uses of IGF-I and IGF Binding Protein Assays --;26 IGF Binding Protein Proteolysis in Various Clinical States --;27 IGF Deficiency --;28 Tumor Hypoglycemia Linked to IGF-II --;29 IGFs in the Evaluation of Acromegaly --;30 IGF in the Treatment of Diabetes --;31 IGF-I Treatment of Growth Hormone Insensitivity.
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| Abstract
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The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri- bution of IGFs in virtually every organ system.
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| Subject
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Insulin-like grow factor-binding proteins.
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Somatomedin -- Pathophysiology.
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Somatomedin -- Physiological effect.
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| LC Classification
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QP552.S65E358 1999
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| Added Entry
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Charles T Roberts, Jr.
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Ron G Rosenfeld
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