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" Adeno-Associated Virus (AAV) Vectors in Gene Therapy "
edited by Kenneth I. Berns, Catherine Giraud.
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BL
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| Record Number
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724210
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b543929
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| Main Entry
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edited by Kenneth I. Berns, Catherine Giraud.
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| Title & Author
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Adeno-Associated Virus (AAV) Vectors in Gene Therapy\ edited by Kenneth I. Berns, Catherine Giraud.
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| Publication Statement
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Berlin, Heidelberg: Springer Berlin Heidelberg, 1996
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| Series Statement
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Current topics in microbiology and immunology, 218.
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(IX, 173 pages 38 illustrations)
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| ISBN
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3540610766
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: 3642802079
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: 3642802095
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: 9783540610762
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: 9783642802072
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: 9783642802096
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| Contents
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List of Contents --;Biology of Adeno-associated Virus --;The Roles of AAV Rep Proteins in Gene Expression and Targeted Integration --;Packaging Systems for Adeno-associated Virus Vectors --;The Challenges of Recombinant Adeno-associated Virus Manufacturing: Alternative Use of Adeno-associated Virus Plasmid/Liposome Complexes for Gene Therapy Applications --;Adeno-associated Virus Vectors for Gene Therapy of the Hematopoietic System --;Adeno-associated Virus Vectors for Gene Transfer into Erythroid Cells --;Adeno-associated Virus 2-Mediated Transduction and Erythroid Lineage-Specific Expression in Human Hematopoietic Progenitor Cells --;Development of Adeno-associated Virus Vectors for Gene Therapy of Cystic Fibrosis --;Adeno-associated Virus-Based Vectors As Antivirals.
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| Abstract
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Viral vectors have been the favored delivery vehicle for gene therapy in recent years. Adeno-associated virus has become a candidate of great interest because of its biological properties which include site specific integration in human chromosome 19. In this volume methods of vector production and use in in vitro and in vivo experi- ments are described, including recent studies with hematopoietic stem cells and non-dividing cells. Various protocols for preparing recombinant AAV vectors and their intracellular delivery are extensively discussed. The first trial of AAV as vector for human gene therapy was conducted in late 1995.
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Medical virology.
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Medicine.
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Microbiology.
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| LC Classification
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QR180.E358 1996
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| Added Entry
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Catherine Giraud
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Kenneth I Berns
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