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" Analytical and chromatographic techniques in radiopharmaceutical chemistry "
edited by Donald M. Wieland, Michael C. Tobes, Thomas J. Mangner.
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BL
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| Record Number
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725335
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b545054
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| Main Entry
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edited by Donald M. Wieland, Michael C. Tobes, Thomas J. Mangner.
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| Title & Author
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Analytical and chromatographic techniques in radiopharmaceutical chemistry\ edited by Donald M. Wieland, Michael C. Tobes, Thomas J. Mangner.
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| Publication Statement
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New York: Springer-Verlag, [2011] ©1986
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| Page. NO
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xviii, 300 pages : illustrations ; 24 cm
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| ISBN
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1461293316
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: 9781461293316
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| Notes
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Updated and expanded versions of presentations at a symposium held June 4, 1984, in Los Angeles, California, under the sponsorship of the Radiopharmaceutical Science Council of the Society of Nuclear Medicine.
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| Contents
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Thin-Layer Chromatography.- 1 Instrumental Evaluation of Thin-Layer Chromatograms.- Sample Application.- Mode Selection for Scanning Densitometry.- Instrumentation for Scanning Densitometry.- Instrument Parameters that Affect the Performance of Slit-Scanning Densitometers.- Protocol for Measuring the Sensitivity of a Slit-Scanning Densitometer.- Qualitative Sample Identification by HPTLC and Scanning Densitometry.- Quantitation of Separated Components by Scanning Densitometry.- Reagents Used to Enhance Fluorescence of Organic Compounds on Thin-Layer Plates.- Radiochromatography on Thin-Layer Plates.- Conclusions.- References.- 2 Radioanalytical Techniques: ITLC, TLC, Mini-Columns, and Electrophoresis.- ITLC.- Radio-TLC.- Mini-Columns.- Electrophoresis.- Conclusions.- Future Considerations.- References.- 3 Radio-Thin-Layer Chromatogram Imaging Systems-Performance and Design.- Instrumentation.- Resolution and Efficiency.- Performance and Operation of the TLC Imaging Systems.- Conclusion.- References.- 4 Detection of Radiochromatograms and Electropherograms with Position- Sensitive Wire Chambers.- The TLC Linear Analyzer.- Data Acquisition System.- Multiplate Detector.- Performance of the Linear Analyzer.- Quantitative Measurements.- Experience with the Linear Analyzer.- Determination of the Radiochemical Purity of Radiopharmaceuticals.- Summary.- References.- High Pressure Liquid Chromatography.- 5 Components for the Design of a Radio-HPLC System.- Columns and Packings.- Components of a Radio-HPLC System.- Conclusion.- References.- 6 Overall Radio-HPLC Design.- Components of the Basic System.- A More Complex Radio-HPLC System 130.- Additional Considerations.- A Specialized HPLC System.- Summary 147.- References.- 7 Quantitation of Radiolabeled Molecules Separated by High Pressure Liquid Chromatography.- Detection of HPLC-Separated Radioactive Compounds.- Detector Design.- Considerations in Use of Detector.- Applications.- Conclusion.- References.- 8 Flow Detector Designs: Build Your Own or Buy?.- Requirements.- Types of Flow Cells.- Data Acquisition and Analysis Considerations.- Conclusions.- References.- Applications.- 9 Radio-HPLC: Application to Organics and Metal Chelate Chemistry.- Stability Under HPLC Conditions.- TC-N2S2 Chelates.- Use of HPLC in Stereochemical Studies of Tc and Re Penicillamine Complexes.- HPLC in the Development and Analysis of HIDAs.- Phosphines.- Phosphonates.- Conclusions.- References.- 10 Concepts and Techniques Used in Metabolic Tracer Studies.- Requirements of Analytical Techniques for Metabolic Studies.- Applications in Tracer Kinetic Models.- Conclusions.- References.- 11. Development of No-Carrier-Added Radiopharmaceuticals with the Aid of Radio-HPLC.- Radio-HPLC.- Scaling Radiolabeling Reactions to nca Levels.- Identification of the nca Radiolabeled Compound.- Examples of nca Radiolabeling Experiments 238.- Conclusions.- References.- 12 From Cyclotron to Patient via HPLC.- HPLC Systems.- Columns.- Solvent Systems.- Dedicated vs General Instruments.- Detectors.- Pre-Columns and Filters.- Is HPLC Truly Necessary?.- Conclusions.- References.- 13 Potential Artifacts in the Chromatography of Radiopharmaceuticals.- Choice of Analytical Methods.- Radiochromatography.- Potential Artifacts/Inconsistencies in Radiochromatography.- Illustrative Examples.- Summary.- References.- 14 HPLC of Radiolabeled Antibodies.- 279.- Theory.- An HPLC System for the Analysis of Radiolabeled Antibodies.- Applications.- Discussion.- Conclusions.- References.
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| Subject
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Liquid chromatography -- Congresses.
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Pharmaceutical chemistry -- Technique -- Congresses.
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Radiopharmaceuticals -- Analysis -- Congresses.
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| LC Classification
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RS431.R34E358 9999
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| Added Entry
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Donald M Wieland
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Michael C Tobes
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Society of Nuclear Medicine (1953- ). Radiopharmaceutical Science Council.
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Thomas J Mangner
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