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" Chronobiology: "
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BL
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| Record Number
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727289
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b547021
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| Title & Author
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Chronobiology: : Biological Timing in Health and Disease.
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| Publication Statement
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Elsevier Science, 2013
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| ISBN
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0123972809
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: 9780123972804
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| Contents
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Front Cover; Chronobiology: Biological Timing in Health and Disease; Copyright; Contents; Contributors; Introduction to Biological Timing in Health and Disease; References; Chapter One: The Suprachiasmatic Nucleus and the Circadian Timing System; 1. Introduction; 2. The Emergence of a Circadian Neurobiology; 3. Anatomical Organization of the SCN; 3.1. General organization; 3.2. Neurochemical organization; 3.3. SCN organization in the rat brain; 3.4. SCN organization in the human brain; 3.5. The subdivision view of SCN organization; 4. Afferent and Efferent Connections 4.1. Intrinsic and commissural connections4.2. Afferent connections; 4.2.1. Visual system projections; 4.2.1.1. Retina; 4.2.1.2. Lateral geniculate nucleus and the pretectal area; 4.3. Efferent organization; 5. Conclusions; 6. Reprise; References; Chapter Two: Epigenetic Regulation of the Molecular Clockwork; 1. Introduction to Epigenetics and the Circadian Clock; 1.1. Histone proteins under circadian control; 1.2. Histone acetylases under circadian control; 1.3. Histone deacetylases under circadian control; 1.4. Other histone protein modifiers associated with the circadian clock Chapter Four: Peripheral Circadian Oscillators: Time and Food1. Introduction; 2. The SCN as Master Clock; 3. The Peripheral Oscillators and Their Relationship with Clock Genes; 4. The SCN as the Driving Force Behind the Oscillators; 5. Synchronization of the Circadian System by the SCN; 6. Timing by Food?; 7. Energy Oscillation in the Cell; 7.1. The NAD/SIRT1 clock gene link; 7.2. Metabolism, AMPK, and clock genes; 8. Heme as Another Metabolic Clock Connection Possibility; 9. The Link Between Clock Genes and Metabolic Genes; 10. Conclusions; Acknowledgments; References Chapter Five: Circadian Clocks, Food Intake, and Metabolism1. Introduction; 2. Physiology; 2.1. Daily rhythm of food intake; 2.2. Daily variations in energy metabolism; 2.3. Cross talk between molecular clocks and intracellular metabolic pathways; 2.4. Peripheral organs and most brain regions: Clocks entrainable by mealtime; 2.5. SCN: The master light-entrainable clock is sensitive to metabolic and reward cues; 3. Pathology; 3.1. Circadian disturbances are associated with metabolic dysfunctions; 3.2. Metabolic pathologies are frequently associated with circadian disturbances
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| Abstract
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This special volume of Progress in Molecular Biology and Translational Science focuses on chronobiology. Contributions from leading authorities Informs and updates on all the latest developments in the field.
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Chronobiology.
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