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" Handbook of immunological properties of nanomaterials "
editors, Marina A. Doborovolskaia, Scott E. McNeil.
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BL
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| Record Number
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727637
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b547371
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| Main Entry
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editors, Marina A. Doborovolskaia, Scott E. McNeil.
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| Title & Author
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Handbook of immunological properties of nanomaterials\ editors, Marina A. Doborovolskaia, Scott E. McNeil.
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| Publication Statement
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Hackensack, N.J.: World Scientific, 2013
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| Series Statement
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Frontiers in nanobiomedical research, v. 1
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(721 p.).
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| ISBN
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129913310X
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: 1628702273
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: 9781299133105
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: 9781628702279
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: 9789814390262
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: 9814390267
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Description based upon print version of record.;Chapter 5 Surface Adsorbates on Nanomaterials and Their Possible Roles in Host Inflammatory and Toxicological Processing Clinton F. Jones, David G. Castner, and David W. Grainger
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| Contents
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Preface; List of Contributors; Chapter 1 Immunological Properties of Engineered Nanomaterials: An Introduction Marina A. Dobrovolskaia and Scott E. McNeil; 1. Introduction; 2. Interaction with Blood Components; 2.1. Hemolysis; 2.2. Coagulation; 2.3. Complement activation; 3. Nanoparticle Uptake by Phagocytic Cells; 4. Immunogenicity; 4.1. Inflammation; 4.2. Antigenicity; 4.3. Adjuvant properties; 5. Immunosuppression; 6. Designing Immunotoxicity Studies; 7. Future Directions; References Chapter 2 Importance of Physicochemical Characterization Prior to Immunological Studies Jeffrey D. Clogston and Anil K. Patri1. Introduction; 2. Key Parameters that Influence Nanomaterial Immunological Properties; 3. Instrumentation for Physicochemical Characterization; 4. Methodologies for Nanomaterial Separation; 5. A Closer Look; 5.1. Dynamic light scattering; 5.1.1. Additional considerations for DLS measurements; 5.2. Zeta potential; 6. Summary; References; Chapter 3 Impact of Nanoparticle Sterilization on Analytical Characterization Nanda Subbarao; 1. Introduction 2. Why Is Sterilization a Challenge for Nanotherapeutics?3. Previous Studies Reviewing the Effects of Various Sterilization Procedures on Nanomaterials; 4. Available Methods for Sterilization; 4.1. Autoclaving; 4.1.1. Impact on NT analytics; 4.2. Filtration; 4.2.1. Impact on NT analytics; 4.3. Gamma irradiation; 4.3.1. Gamma irradiation of SLNs; 4.3.2. Gamma irradiation and liposomes; 4.3.3. Mitigating the effects of gamma irradiation; 4.3.4. Gamma irradiation remains a method of choice for NTs; 4.3.5. Impact on NT analytics; 4.4. Gaseous ethylene oxide; 4.4.1. Impact on NT analytics 4.5. High hydrostatic pressure sterilization4.6. Formaldehyde; 5. Comparison of Different Methods for Sterilization; 6. Impact on Nanotherapeutic Analytics; 7. Conclusions; References; Chapter 4 Endotoxin and Engineered Nanomaterials Marina A. Dobrovolskaia and Scott E. McNeil; 1. Introduction; 2. What Endotoxin Is and Why It Is Important to Study in Nanoformulations; 3. Methods Used for Endotoxin Detection and Quantification; 3.1. Traditional methods; 3.2. Alternative methods; 3.2.1. Gel-staining-based methods; 3.2.2. Ligand binding-based methods; 3.2.3. Mass spectrometry-based methods 3.2.4. Macrophage activation test4. Estimating Endotoxin in Nanoformulations; 4.1. Nanoparticle interference with traditional methods; 4.2. Evaluation of interference; 4.3. How to choose an appropriate LAL format; 4.4. Application of non-traditional methods; 4.4.1. Gel-based assay; 4.4.2. Western blot-based assay; 5. Use of Traditional Endotoxin-Neutralizing Reagents in Nanoparticle Research; 5.1. Case study 1; 5.2. Case study 2; 6. Minimizing Contamination and Interference; 7. Purification and Depyrogenation of Nanoformulations; 8. Conclusions and Future Directions; References
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| Abstract
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Suitable for students, scientific consultants, reviewers and policy makers, this title provides a comprehensive overview of literature, methodologies, translational and regulatory considerations in the field of nanoimmunotoxicology.
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Nanostructured materials -- Handbooks, manuals, etc.
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| Subject
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Nanostructured materials -- Health aspects.
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| Subject
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Nanotechnology -- Health aspects.
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| LC Classification
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TA418.9.P6E358 2013
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| Added Entry
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Marina A Doborovolskaia
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Marina A Dobrovolskaia
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Scott E McNeil
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