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" Heparin : "
edited by Ralph A. Bradshaw, Stanford Wessler.
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BL
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| Record Number
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728812
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b548565
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| Main Entry
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edited by Ralph A. Bradshaw, Stanford Wessler.
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| Title & Author
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Heparin : : Structure, Function, and Clinical Implications\ edited by Ralph A. Bradshaw, Stanford Wessler.
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| Publication Statement
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Boston, MA: Springer US, 1975
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| Series Statement
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Advances in experimental medicine and biology, 52.
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| Page. NO
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(volumes)
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| ISBN
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1468409468
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: 1468409484
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: 9781468409468
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: 9781468409482
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| Contents
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Section 1 Structural Aspects.- Molecular Properties.- The Chemistry of Heparin.- Crystalline Structure of Heparin.- Three-Dimensional Model of Heparin.- Biosynthesis.- Heparin and Heparin-Like Substances of Cells.- Biosynthesis of Heparin.- Metabolism of Macromolecular Heparin in Murine Neoplastic Mast Cells.- Demonstration of Endogenous Heparin in Rat Blood.- Biological Properties.- Relation of Chemical Structure of Heparin to Its Anticoagulant Activity.- Synthesis and Properties of Heparin Derivatives.- Low-Molecular-Weight Derivative of Heparin That Is Orally Active in Mice.- Heparin Is an Anionic Hydrated Anticoagulant.- Analytical and Pharmacological Considerations.- What Is "Heparin"?.- Determination of Heparin in Small Tissue Samples.- Identification and Quantification of Tissue Heparin by Microelectrophoresis: A Critique.- Standards for Heparin.- Application of the Kinetics of Heparin to the Formulation of Dosage Schedules.- Section 2 Functional Aspects.- Effect on Blood Coagulation: Interaction with Antithrombin III.- Antithrombin III: A Backward Glance O'er Travel'd Roads.- The Coagulation-Fibrinolytic Mechanism and the Action of Heparin.- Heparin Interaction with Activated Factor X and Its Inhibitor.- Evidence of a Catalytic Role of Heparin in Anticoagulation Reactions.- Structural and Functional Relationships of Human Antithrombin III and Alphas-Antitrypsin.- Interaction with Platelets.- Heparin, Lysolecithin, and Platelet Function.- Effect of Lung and Gut Heparin on Experimental Arterial Thrombosis.- Effect on Lipoprotein Lipase.- Lipoprotein Lipase.- "Lipolipin": A Glycoprotein Inhibitor of Postheparin Plasma Lipoprotein Lipase.- Other Effects.- Heparin as an Inhibitor of Mammalian Protein Synthesis.- The Effect of Heparin on Oxygen Transport from Blood to Tissues.- Section 3 Clinical Aspects.- Antithrombotic Efficacy.- Clinical Implications of Heparin.- Low-Dose Heparin in the Prevention of Venous Thromboembolism - Rationale and Results.- Long-Term Use of Minidose Heparin in Post-Myocardial Infarction.- Wall-Bonded Heparin - Historical Background and Current Clinical Applications.- Surface-Bonded Heparin.- Toxicity.- Heparin-Induced Osteopenia: An Appraisal.- Panel Discussion.- The Use of Heparin as an Antithrombotic Agent.- Participants.
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| Subject
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Cardiology.
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Medicine.
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| LC Classification
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QP702.H4E358 1975
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| Added Entry
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Ralph A Bradshaw
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Stanford Wessler
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