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" Enzyme-Prodrug Strategies for Cancer Therapy "
edited by Roger G. Melton, Richard J. Knox.
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BL
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| Record Number
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728816
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b548569
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| Main Entry
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edited by Roger G. Melton, Richard J. Knox.
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| Title & Author
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Enzyme-Prodrug Strategies for Cancer Therapy\ edited by Roger G. Melton, Richard J. Knox.
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| Publication Statement
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Boston, MA: Springer US, 1999
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| Page. NO
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(xiii, 257 pages)
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| ISBN
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1461548233
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: 9781461548232
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| Contents
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1 Introduction --;1. Introduction --;References --;2 Prodrugs in Cancer Chemotherapy --;1. Introduction --;2. Uses of Prodrugs in Cancer Chemotherapy --;3. Clinical Use of Prodrugs --;References --;3 Factors Influencing Tumor-Selective Localization of Antibody Conjugates --;1. Introduction --;2. Tumor Physiology --;3. Properties of the Monoclonal Antibody Vector --;4. Tumor Antigens --;5. Manipulation of Tumor Antigenic Expression --;6. Evaluation of Antigenic Targets for ADEPT --;7. In VitroCell Culture Problems --;8. Unforeseen Problems of Specificity --;References --;4 Enzymes and Prodrugs Used for ADEPT --;1. Introduction --;2. Enzymes and Prodrugs Used for ADEPT --;3. Conclusions --;References --;5 The Design and Synthesis of Prodrugs for Antibody-Directed Enzyme Prodrug Therapy (ADEPT) --;1. Introduction --;2. Prodrugs Used in ADEPT --;3. Summary --;References --;6 Preparation and Purification of Antibody-Enzyme Conjugates for Therapeutic Applications --;1. Introduction --;2. Production of Antibody Fragments --;3. Chemical Coupling of Antibodies to Enzymes --;4. Alternatives to Chemical Coupling --;5. Purification of Conjugates --;6. Postpurification Modifications --;7. Future Developments --;References --;7 Phage Technology for Producing Antibody-Enzyme Fusion Proteins --;1. Introduction --;2. Antibody-Targeted Cancer Therapy --;3. Potential of Engineered Antibodies for Therapy --;4. Single-chain Fv Antibodies --;5. The Phage System --;6. Target Antigens --;7. Engineered Antibody-Enzyme Fusion Proteins in ADEPT --;8. Practical Considerations --;9. Conclusions --;References --;8 Early Clinical Studies with ADEPT --;1. Introduction --;2. Initial Clinical Studies --;3. Second Clinical Study --;4. Conclusions --;References --;9 Gene-Directed Enzyme Prodrug Therapy (GDEPT) of Cancer --;1. Introduction --;2. Why GDEPT? --;3. Enzymes and Prodrugs Used for GDEPT --;4. Conclusions --;References --;Enzymes and Prodrugs Proposed for Cancer Therapy --;References.
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| Abstract
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Antibody-directed enzyme prodrug therapy (ADEPT) directly addresses the major problem in cancer chemotherapy-its lack of selectivity. ADEPT offers a novel field of opportunities in the therapy of systemic cancer and may be a major advance for the treatment of solid tumours. This book is the first to describe ADEPT in detail.
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| Subject
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Immunology.
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Internal medicine.
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Medicine.
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| LC Classification
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RC271.A66E358 1999
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| Added Entry
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Richard J Knox
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Roger G Melton
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