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" Autoimmunity and the Pathogenesis of Diabetes "
edited by Fredda Ginsberg-Fellner, Robert C. McEvoy.
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BL
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728874
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b548627
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| Main Entry
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edited by Fredda Ginsberg-Fellner, Robert C. McEvoy.
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Autoimmunity and the Pathogenesis of Diabetes\ edited by Fredda Ginsberg-Fellner, Robert C. McEvoy.
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| Publication Statement
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New York, NY: Springer New York, 1990
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| Series Statement
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Endocrinology and Metabolism, Progress in Research and Clinical Practice, 4.
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(xii, 296 pages 71 illustrations)
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| ISBN
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146123218X
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: 9781461232186
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| Contents
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1. The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present --;Autoimmunity --;The Concept of IDDM as an Autoimmune Disease --;The Association Between IDDM and HLA --;Etiologic Factors with Implications for the Pathogenesis of IDDM --;The Autoantigen in IDDM --;Presentation of Autoantigen --;Autoantigen Recognition in IDDM --;The Effector Phase in IDDM --;Conclusion --;2. Immunogenetics and the Pathogenesis of Insulin-Dependent Diabetes Mellitus --;Genetic Background --;Environmental Factors --;Speculations on the Mechanism of IDDM Pathogenesis --;3. Association of Insulin-Dependent Diabetes Mellitus and Other Autoimmune Diseases --;IDDM and Thyroid Autoimmunity --;Other Endocrinopathies Associated with Type 1 Diabetes Mellitus --;How Does Autoimmune Disease Develop? --;Can Autoantibodies Affect More Than One Gland? Are They Mono- or Polyclonal? --;Summary and Conclusions --;4. The Humoral Anti-Islet Immune Response: Cytoplasmic Islet-Cell Antibodies: Technical Aspects and Clinical Applications --;Assays for ICA Determination --;Approaching Standardization of the Cytoplasmic ICA Test --;Clinical Application of the ICA Test --;Synopsis, Recommendations, and Conclusions --;5. The Humoral Anti-Islet Response: Biochemical Characterization --;Autoantigens Detected in Human Islets --;Autoantigens May Define Disease Specificity in Human Autoimmunity --;Western Blotting Analysis of Islet Autoantigens --;Analyzing Circulating Immune Complexes in Diabetes --;Summary --;6. The Humoral Anti-Islet Immune Response: Immunochemical Studies of Glycoconjugate Antigens --;What Are Gangliosides? --;Immunochemical Characterization of Monoclonal Antibody-Defined, Islet-Cell Antigens --;Immunochemical Properties of the Autoantigen(s) of Pancreatic Islets --;Extraction and Partial Purification of the ICA Glycolipid Antigen --;Glycolipid Antigens in Animal Models of Type I Diabetes --;Multiplicity of Antigens in Humoral Autoimmunity of Type I Diabetes --;Monoclonal Antibody-Defined, Islet-Cell Glycolipid Antigens --;Physiological Roles of Islet-Cell Gangliosides --;Antibodies to Glycolipids in Diseases Other than Type I Diabetes Mellitus --;Immunogenicity of Glycolipids --;T-Cell Reactivity to Glycolipid Antigens --;Final Comments --;7. Insulin Autoantibodies --;8. Cell-Mediated Anti-Islet-Cell Immune Response: Clinical Experience and Lessons from Animal Models --;Cell-Mediated, Anti-Beta-Cell Autoimmunity in Human Diabetes --;Diabetes Induced by Multiple, Subdiabetogenic Doses of Streptozotocin --;Diabetes in the Bio-Breeding Rat --;Diabetes in Nonobese Diabetic Mice --;Summary and Conclusions --;9. The Pathogenesis of Immunologically Mediated Diabetes --;Mechanism of the Disease Process --;Disease Recurrence Model --;Disease Recurrence in Islet Grafts is CD4 T-Cell Dependent --;Free Radical Involvement in the Disease Process --;Disease Recurrence in the Grafted Tissue: A Summary --;Lessons from Fetal Pancreas Transplantation --;Effect of Cyclosporine on Disease Recurrence --;10. Viral Pathogenesis of Insulin-Dependent Diabetes Mellitus --;Direct Cytolytic Viral Infection of Beta-Cells --;Association of Virus Infection with Autoimmune IDDM --;Persistent Infection of Pancreatic Beta-Cells and Mild Hyperglycemia --;Conclusion --;11. Immune Intervention in Diabetes: State of the Art and Future Directions --;Experimental Immunotherapy in IDDM of Recent Onset --;Open Studies of Immunomodulatory Therapies in IDDM --;Randomized Control Trials of the Effects of Cyclosporin in IDDM --;Efficacy and Safety of Immunosuppression in Remission Induction in IDDM --;Timing of Immunomodulatory Interventions in IDDM --;IDDM in Remission: Endocrine Metabolic Status and Its Possible Implications --;Strategies for Continuing Studies of Immunotherapy in IDDM --;Summary and Conclusions.
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| Abstract
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. . . . . . . . . . . . . . ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Xl . . . . . . . . . . . . . The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present . . . . . . . . . . . . . . . .
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Human genetics.
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Immunology.
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Medicine.
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| Added Entry
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Fredda Ginsberg-Fellner
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Robert C McEvoy
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