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" Free radical reactions in medicine "
János Fehér, Géza Csomós, András Vereckei.
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BL
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729899
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b549655
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János Fehér, Géza Csomós, András Vereckei.
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Free radical reactions in medicine\ János Fehér, Géza Csomós, András Vereckei.
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| Publication Statement
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Berlin, Heidelberg: Springer, 2012. ©1987
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xii, 199 pages ; 25 cm
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3642831060
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: 9783642831065
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| Contents
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I The Chemistry of Free Radical Reactions.- 1 The Definition and Reactions of Free Radicals.- 2 Lipid Peroxidation.- 3 The Most Important Physical and Chemical Properties of Molecular Oxygen: Radicals of Molecular Oxygen.- 3.1 Reduction.- 3.2 Excitation.- 4 Reactions in which ROIs are Formed.- 5 Summary.- II Control of Free Radical Reactions in Biological Systems.- 1 Control by Membrane Structure.- 2 Control by Specific Molecular Structure.- 3 Scavengers and Antioxidants.- 4 Cellular Enzymatic Defence Against Radicals of Molecular Oxygen.- 5 Antioxidant Defence of the Extracellular Space.- 6 Summary.- III Physiological Free Radical Reactions.- 1 The Role of Free Radical Reactions in Phagocytosis.- 2 Free Radicals Generated During Platelet Activity.- 3 Free Radical Generation in Mitochondrial and Microsomal Electron Transport Chains and in Peroxisomes.- 4 Role of Free Radicals in the Synthesis and Degradation of Various Biomolecules: Free Radical Formation During Autoexidation of Biomolecules.- 4.1 Arachidonic Acid Metabolism.- 4.2 Role of Free Radical Reactions in the Synthesis of Adrenocortical Hormones and in the Functional Division of the Cortex.- 4.3 The Role of Free Radical Reactions in the Function of Melanins.- 4.4 The Modulating Effect of Free Radicals on the Activity of Enzymes: Free Radical Generation by Autooxidation of Biomolecules and During Enzyme Function.- 5 The Role of Free Radicals in Reproduction and Embryonic Development.- 6 Summary.- IV Pathological Free Radical Reactions: General Aspects.- 1 Damage of Enzymes and Proteins Caused by Free Radicals.- 2 Damage of the Cell Membrane and Subcellular Organelles.- 3 Fluorescent Molecular Damage and Lipofuscin Pigments.- 4 Free Radical Damage of Nucleic Acids and Their Components.- 5 Connection Between LPO and Tissue Damage.- 6 Summary.- V Demonstration of Free Radical Reactions.- 1 Summary.- VI Clinical Importance of Free Radical Reactions and Their Role in the Pathogenesis of Various Human Diseases.- 1 The Radical Theory of Oxygen Toxicity.- 1.1 Summary.- 2 The Role of Free Radical Reactions in Inflammation.- 2.1. Summary.- 3 Relation of Free Radical Reactions to the Immune System and Their Role in Immunopathological Syndromes.- 3.1 Rheumatoid Arthritis.- 3.2 Systemic Lupus Erythematosus.- 3.3 Summary.- 4 The Free Radical Theory of Ageing.- 4.1. Summary.- 5 The Role of Free Radical Reactions in the Pathogenesis of Some Neurological Diseases.- 5.1 Chronic Organic Brain Syndrome.- 5.2 Alzheimer's Disease.- 5.3 Parkinson's Disease.- 5.4 The Role of Free Radicals in Neurotransmission.- 5.5 Psychiatric Syndromes.- 5.6 Cerebrovascular Syndromes and Trauma of the Central Nervous System.- 5.7 Cerebral Lipofuscinosis.- 5.8 Summary.- 6 The Free Radical Pathogenesis of Atherosclerosis.- 6.1 Summary.- 7 Hypertension and Free Radical Reactions.- 7.1 Summary.- 8 Free Radical Reaction in Ischaemic Damage.- 8.1 Ischaemic Cerebrovascular Disease.- 8.2 Myocardial Ischaemia and Infarction.- 8.3 Renal Ischaemia.- 8.4 Shock.- 8.5 Transplantation.- 8.6 Summary.- 9 Free Radical Reactions in Other, Nonischaemic Heart Diseases.- 9.1 Summary.- 10 The Role of Free Radical Reactions in Carcinogenesis: Connection Between Atherosclerosis, Ageing, Carcinogenesis and Mutagenesis.- 10.1 Summary.- 11 Free Radical Reactions and Mutagenesis.- 11.1. Summary.- 12 Free Radical Mechanisms in the Effect of Drugs and Chemicals.- 12.1. Summary.- 13 Free Radical Reactions in Pulmonary Diseases.- 13.1 Emphysema.- 13.2 Bronchial Asthma.- 13.3 Acute Respiratory Distress Syndrome in Adults.- 13.4 Silicosis and Asbestosis.- 13.5 Summary.- 14 Free Radical Reactions in Hepatic Diseases.- 14.1 Alcoholic Liver Damage.- 14.2 Hepatic Damage Caused by Drugs and Chemical Agents.- 14.3 Wilsen's Disease.- 14.4 Haemochromatosis.- 14.5 Dubin-Johnson Syndrome.- 14.6 Antioxidant Effect of Hepatoprotective Drugs.- 14.6.1 Cyanidanol-3 and Lysosomal Enzyme Activity.- 14.6.2 Dihydroquinoline-type Antioxidants and Acute Liver Lesions.- 14.6.3 Effect of AICA Phosphate on Lymphocyte Populations in Chronic Active Hepatitis.- 14.6.4 Silymarin as a Free Radical Scavenger.- 14.7 Summary.- 15 Free Radical Reactions in Diseases of the Gastrointestinal Traet.- 15.1 Ischaemic Intestinal Disease.- 15.2 Necrotizing Enterocolitis.- 15.3 Inflammatory Intestinal Diseases.- 15.4 Radiation Injury of the Intestines.- 15.5 Gastric and Duodenal Ulcer.- 15.6 Acute Pancreatitis.- 15.7 Summary.- 16 Free Radical Pathogenesis of Amyloidosis.- 16.1 Summary.- 17 Diabetes Mellitus and Pathological Free Radical Reactions.- 17.1 Summary.- 18 Haematological Aspects.- 18.1 Unstable Haemoglobins.- 18.2 ?-Thalassaemia.- 18.3 Glucose-6-phosphate Dehydrogenase Deficiency.- 18.4 Erythropoietic Protoperphyria.- 18.5 Paroxysmal Nocturnal Haemoglobinuria.- 18.6 Iron Deficiency Anaemia.- 18.7 Spur Cell Anaemia.- 18.8 Abetalipoproteinaemia.- 18.9 Haemolytic Anaemia of the Newborn.- 18.10 Fanconi's anaemia.- 18.11 Summary.- 19 Free Radical Reactions in Neonatal Diseases.- 19.1 Neonatal Diseases Connected with Oxygen Toxicity.- 19.1.1 Haemolytic Disease.- 19.1.2 Retrolental Fibroplasia.- 19.1.3 Bronchopulmonary Dysplasia.- 19.1.4 Hyaline Membrane Disease.- 19.1.5 Persistent Pulmenary Hypertension in Neonates.- 19.2 Hyperbilirubinaemia of Neonates.- 19.3 Summary.- 20 Free Radical Reactions in Infectious Diseases.- 20.1 Summary.- 21 Hormones and Free Radical Reactions.- 21.1 Summary.- 22 Ophthalmological Aspects.- 22.1 Summary.- 23 Free Radical Reactions in Muscular Dystrophy.- 23.1 Myotonic Dystrophy.- 23.2 Duchenne-type Muscular Dystrophy.- 23.3 Summary.- 24 Free Radical Reactions in Pyelonephritis, Uraemia and urological Diseases.- 24.1 Summary.- 25 Other Diseases: Down's Syndrome.- 25.1 Summary.- 26 The Role of Free Radical Reactions in Photobiology.- 26.1 Summary.- VII Defence Against Free Radical Reactions.- 1 Minimizing Exposure.- 2 Antioxidants.- 3 Summary.- Epilogue.- References.
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| Subject
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Free radicals (Chemistry) -- Physiological effect.
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| LC Classification
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QP527.J366 9999
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| Added Entry
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András Vereckei
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G Csomós
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János Fehér
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