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" Complex Carbohydrates of Nervous Tissue "
edited by Richard U. Margolis, Renée K. Margolis.
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BL
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| Record Number
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730041
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b549797
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| Main Entry
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edited by Richard U. Margolis, Renée K. Margolis.
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| Title & Author
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Complex Carbohydrates of Nervous Tissue\ edited by Richard U. Margolis, Renée K. Margolis.
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| Publication Statement
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Boston, MA: Springer US, 1979
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| Page. NO
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(XVIII, 402 pages 53 illustrations)
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| ISBN
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1461329256
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: 1461329272
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: 9781461329251
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: 9781461329275
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| Contents
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1 Structure and Distribution of Gangliosides --;1. Introduction --;2. Structures --;3. Distribution --;References --;2 Biosynthesis and Metabolism of Gangliosides --;1. Introduction: Location and Types of Gangliosides --;2. Biosynthesis of Brain Gangliosides --;3. Turnover of Brain Gangliosides --;1. Catabolism of Nervous System Gangliosides --;2. Influence of Physicochemical Properties on Metabolism --;References --;3 Structure and Distribution of Glycoproteins and Glycosaminoglycans --;1. Introduction --;2. Structure --;3. Distribution --;4. Conclusions --;References --;4 Biosynthesis of Glycoproteins --;1. Introduction --;2. Sugar Nucleotide: Glycoprotein Glycosyltransferases --;3. Lipid-Mediated Glycosyltransferases --;4. Subcellular Site(s) of Sugar-Nucleotide- and Lipid-Mediated Glycosyltransferases --;5. Summary and Concluding Remarks --;References --;5 Biosynthesis of Glycosaminoglycans --;1. Introduction --;2. Metabolism of Glycosaminoglycans in Nervous Tissue --;3. Biosynthesis of Nucleotide Monosaccharides and Sulfate Precursors of Nervous Tissue Glycosaminoglycans --;4. Biosynthesis of Glycosaminoglycans in Nervous Tissue --;5. Subcellular Distribution of Glycosyltransferases and Sulfotransferases in Nervous Tissue --;6. Summary and Conclusions --;References --;6 Brain Glycosidases --;1. Introduction --;2. Sialidase --;3.?-Galactosidase --;4.?-N-Acetylhexosaminidase --;5.?-L-Fucosidase --;6.?-Mannosidase --;7. Enzymes That Degrade Brain Glycosaminoglycans, and Other Glycohydrolases --;8. Biology of Glycosidases --;References --;7 Histochemistry and Cytochemistry of Glycoproteins and Glycosaminoglycans --;1. Introduction --;2. Historical Background --;3. Glycosaminoglycans --;4. Glycoproteins: Lectin Cytochemistry --;5. Toxin and Antibody Cytochemistry --;6. Summary --;References --;8 Glycoproteins of the Synapse --;1. Introduction --;2. Current Status --;3. Outlook --;References --;9 Surface Glycoconjugates in the Differentiating Neuron --;1. Introduction --;2. An Approach to the Mapping of Cell-Surface Carbohydrates --;3. Regional and Type-Specific Lectin Receptor Content in the Plasmalemma of Growing Neurons --;4. Dynamics of Surface Glycoconjugates during Neuritic Elongation --;5. Concluding Remarks --;References --;10 Histochemistry of Polyanions in Peripheral Nerve --;1. Introduction --;2. Histochemistry of Peripheral Nerve --;3. Chemical Nature of Peripheral Nerve Polyanions --;4. Functional Implications --;References --;11 Glycoproteins in Myelin and Myelin-Related Membranes --;1. Historical Background and Introduction --;2. Peripheral Myelin --;3. Central Myelin --;4. Relevance for Myelin Structure and Perspectives --;References --;12 Axonal Transport of Complex Carbohydrates --;1. The Phenomenon of Axonal Transport --;2. Axonal Transport of Complex Carbohydrates --;3. Turnover and Redistribution of Axonally Transported Molecules --;4. Overview and Functional Considerations --;References --;13 Regional Aspects of Neuronal Glycoprotein and Glycolipid Synthesis --;1. Introduction --;2. Distribution of [3H]Glycoproteins and [3H]Glycolipids in R2 after Intrasomatic Injection of [3H]Fucose or [3H]-N-Acetylgalactosamine --;3. Association of Individual Glycoprotein Components with Subcellular Organelles in the Cell Body --;4. Selective Export of Newly Synthesized Glycoproteins into Axons --;5. Modification of Macromolecules in the Axon of R2 --;6. Afterword --;References --;14 Complex Carbohydrates of Cultured Neuronal and Glial Cell Lines --;1. Introduction --;2. Glycolipid Metabolism in Neurotumor Cell Lines --;3. Glycoprotein Metabolism in Neurotumor Cell Lines --;4. Collagen Synthesis in Neurotumor Cell Lines --;5. Glycosaminoglycan Synthesis in Neurotumor Cell Lines --;6. Relevance of Studies on Neurotumor Cell Lines to Whole Brain and Relationship to Studies on Individual Cell Types --;7. Conclusions --;References --;15 Complex Carbohydrates of Secretory Organelles --;1. Introduction --;2. Complex Carbohydrates of Secretory Granules and Vesicles --;3. Role of Complex Carbohydrates in the Assembly and Function of Secretory Organelles --;References --;16 Glycoprotein Storage Diseases and the Mucopolysaccharidoses --;1. Introduction --;2. Glycoproteins of Nervous Tissue --;3. Inborn Errors of Glycoprotein Catabolism --;4. Glycosaminoglycans of Nervous Tissue --;5. Inborn Errors of Glycosaminoglycan Catabolism (the Mucopolysaccharidoses) --;6. Effect of Lysosomal Glycosaminoglycan Storage on CNS Function and Prospects for Therapy --;References --;17 Perspectives and Functional Implications --;1. Biosynthesis and Metabolism --;2. Axonal Transport --;3. Synaptic Membranes --;4. Cell-Cell Interactions and Neuronal Recognition --;References --;Appendix I: Developmental Changes in Complex Carbohydrates of Brain --;Appendix II: Turnover of Complex Carbohydrates in Rat Brain --;Appendix III: The Human Sphingolipidoses.
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| Abstract
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It is only relatively recently that neurochemists and neurobiologists have shown appreciable interest in the class of macromolecules now generally re- ferred to as complex carbohydrates, although gangliosides were, of course, first identified and studied in brain.
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| Subject
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Neurosciences.
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| LC Classification
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QP701.E358 1979
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| Added Entry
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Renée K Margolis
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Richard U Margolis
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