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" Absorption of Orally Administered Enzymes "
by Michael L.G. Gardner, Klaus-Jürgen Steffens.
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BL
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| Record Number
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731253
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b551039
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| Main Entry
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by Michael L.G. Gardner, Klaus-Jürgen Steffens.
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| Title & Author
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Absorption of Orally Administered Enzymes\ by Michael L.G. Gardner, Klaus-Jürgen Steffens.
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| Publication Statement
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Berlin, Heidelberg: Springer Berlin Heidelberg, 1995
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| Page. NO
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(x, 96 pages 60 illustrations)
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| ISBN
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354058837X
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: 3642795110
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: 3642795137
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: 9783540588375
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: 9783642795114
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: 9783642795138
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| Contents
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A Review of Current Knowledge of Gastrointestinal Absorption of Intact Proteins Including Medicinal Preparations of Proteolytic Enzymes --;Persorption-Critism and Agreement as Based upon In Vitro and In Vitro Studies on Mammals --;Modes of Absorption of Macromolecular Substances --;The Quantitative Absorption of Orally Administered Proteins and Histological Evidence of Enzymes in the Wound --;Oral Route of Peptide and Protein Drug Delivery --;Intestinal Absorption of Undegraded Bromelain in Humans --;Investigations on the Effect of Protease Mixtures on Vessels --;Parameters of Serological Effects Following Oral Administration of Mulsal N: Results of a Double-Blind Study --;Enzyme Influences on Adhesion Molecules and Their Clinical Implications --;Bioavailability of Therapeutically Used Hydrolytic Enzymes.
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| Abstract
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This book is a compilation of papers that arose from a multidisciplinary workshop held at the Walter-Straub-Institute for Pharmacology and Toxicology in Munich in September 1993 to review the current state fo knowledge relating to the oral administration of enzymes, especially proteases, as therapeutic agents. Issues such as the gastrointestinal absorption of intact macromolecules and the efficacy of oral enzyme preparations have been critically discussed, and areas requiring further investigation have been identified. This is the first time that objective information on this topic has been collected together from so many relevant disciplines. While absorption of intact proteins is now a proven phenomenon, its exploitation in therapeutics is still in its infancy, and this book should provide a sound scientific background for such applications and for further research.
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Immunology.
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Medicine.
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Toxicology.
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| LC Classification
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QP601.3B965 1995
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| Added Entry
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K -J Steffens
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Michael L G Gardner
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