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" Opioid Dependence Mechanisms and Treatment. "
Wikler, Abraham.
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BL
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| Record Number
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731592
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| Doc. No
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b551378
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| Main Entry
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Wikler, Abraham.
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| Title & Author
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Opioid Dependence Mechanisms and Treatment.\ Wikler, Abraham.
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| Publication Statement
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Springer Verlag, 2012
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| Page. NO
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pages
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| ISBN
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1468438689
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: 9781468438680
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| Contents
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1 The Problems of Opioid and Other Drug Dependencies.- Prevalence and Complications.- Nonopioid Drug-Dependence Syndromes.- Barbiturate, Nonbarbiturate Sedative, and "Minor Tranquilizer" Dependence.- Alcohol Dependence.- Amphetamine Dependence.- Cocaine Dependence.- Hallucinogen Dependence.- Cannabis (Marijuana, Hashish) Dependence.- Tobacco Dependence.- References.- 2 The Etiology of Opioid Dependence.- Definitions and Dynamics.- Personality Studies.- Socioenvironmental Studies.- Mode of Spread of Opioid Dependence.- Prognosis.- References.- 3 Opioid Analgesics and Opioid Antagonists.- Opioid Analgesics.- Morphine.- Effects of Single Doses in the Nontolerant State.- Tolerance and Physical Dependence.- Heroin.- Methadone.- Meperidine.- Codeine.- d-Propoxyphene.- Pentazocine.- Opioid Antagonists.- Nalorphine.- Effects of Single Doses in the Drug-Free State.- Tolerance and Physical Dependence.- Opioid-Antagonistic and Opioid-Blocking Actions in the Nontolerant State.- Opioid-Antagonistic and Opioid-Blocking Actions in the Tolerant State.- Cyclazocine.- Naloxone and Naltrexone.- References.- 4 Opioid Receptors and Endogenous Opioid Peptides.- Opioid Receptors.- Endogenous Opioid Peptides (Enkephalins and Endorphins).- Possible Functions of Enkephalins and Endorphins.- Analgesia.- Physical Dependence.- Mental Disorders.- References.- 5 Mechanisms of Opioid Analgesia.- The Nature of Pain and Its Relief by Morphine.- Sites of Morphine's Antinociceptive Actions in the Central Nervous System.- Spinal Cord.- Brain Stem.- Cerebral Cortex.- References.- 6 Theories of Tolerance to and Physical Dependence on Opioids.- General Theories of Tolerance to and Physical Dependence on Morphine.- Homeostatic Counteradaptation.- Cellular Counteradaptation.- Dual Action.- Theories of the Mechanisms of Counteradaptation to the Agonistic Effects of Drugs.- Disuse Supersensitivity.- Pharmacological Redundancy.- New Receptors.- Enzyme Expansion.- Immune Mechanisms.- Learning Factors.- References.- 7 Conditioning Processes in Opioid Dependence and in Relapse.- Operant Conditioning of Opioid-Acquisitive Behavior.- Classical Conditioning of the Opioid Agonist-Abstinence Cycle and Interoceptive Conditioning of Opioid-Seeking Behavior.- Classical Conditioning of the Opioid-Antagonist-Precipitated Opioid-Abstinence Syndrome.- Occurrence of Classically Conditioned Responses in Street Addicts.- Implications of Conditioning Factors for Relapse and Treatment.- References.- 8 Diagnosis and Treatment of Opioid Dependence.- Diagnosis.- Physical Dependence.- Opioid Use.- Treatment.- Opioid Poisoning.- Opioid Dependence.- Detoxification.- Detoxification Followed by Narcotic-Antagonist Maintenance.- Methadone Maintenance (with or without Eventual Detoxification).- Levomethadyl Maintenance.- References.
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| LC Classification
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RC568.O58W555 2012
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| Added Entry
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Wikler, Abraham.
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