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" Quantitative Aspects of Allosteric Mechanisms "
by Alexander Levitzki.
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BL
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| Record Number
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731963
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b551749
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| Main Entry
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by Alexander Levitzki.
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| Title & Author
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Quantitative Aspects of Allosteric Mechanisms\ by Alexander Levitzki.
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| Publication Statement
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Berlin, Heidelberg: Springer Berlin Heidelberg, 1978
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| Series Statement
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Molecular biology, biochemistry, and biophysics, 28.
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| ISBN
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3642812317
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: 3642812333
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: 9783642812316
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: 9783642812330
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| Contents
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1 Basic Concepts of Allosteric Control --;2 The Structure of Multisubunit Proteins --;I. General Principles --;II. Other Types of Protein Assemblies --;3 Cooperativity in Multisubunit Proteins --;The Basic Concepts --;I. The Hill Equation --;II. The General Adair Equation --;III. The Statistical Correction --;IV. The Hill Coefficient in Terms of Intrinsic Ligand Affinities --;V. The Hill Coefficient at 50% Ligand Saturation --;VI. The Maximal Hill Coefficient --;VII. The Limiting Values of the Hill Slope --;VIII. The Allosteric Dimer --;IX. The Multi-Dimer Case --;X. The Allosteric Tetramer --;XI. The General Tetrameric Case --;4 The Energy of Subunit Interactions --;I. Determination of Intersubunit Interaction Energy --;II. The Hill Coefficient and the Intersubunit Interaction Energy --;III. The Meaning of Intersubunit Energy of Interaction --;5 Molecular Models for Cooperativity and Allosteric Interactions --;I. Introduction --;II. The Monod-Wyman-Changeux (MWC) Concerted Model --;III. The Koshland-Némethy-Filmer (KNF) Sequential Model --;IV. The Conformational State of the Protein --;V. Comparison Between the KNF Model and the MWC Model --;6 Special Types of Cooperative Systems --;I. Cooperativity Resulting from Ligand-Coupled Protein Association or Dissociation --;II, Negative Cooperativity --;III. Protein Association and Dissociation Coupled to Ligand Binding --;1, Dimerization Coupled to Ligand Binding --;2. Monomer Multimer Equilibrium Coupled to Ligand Binding --;References.
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| Abstract
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Special emphasis has been given to the analysis of the Hill coefficient and its meaning both in thermodynamic terms and in terms of the two allosteric models: the concerted model of Monod, Wyman and Changeux and the sequential model of Koshland, Nemethy and Filmer.
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Allosteric Regulation.
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Life sciences.
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Medicine.
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| LC Classification
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QP552.A436B935 1978
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| Added Entry
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Alexander Levitzki
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