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" Regulation of Haemoglobin Synthesis "
by J. Neuwirt, P. Poňka.
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BL
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| Record Number
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734108
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b553934
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| Main Entry
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by J. Neuwirt, P. Poňka.
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| Title & Author
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Regulation of Haemoglobin Synthesis\ by J. Neuwirt, P. Poňka.
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| Publication Statement
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Dordrecht: Springer Netherlands, 1977
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(208 pages)
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| ISBN
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9401010900
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: 9789401010900
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| Contents
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1. Introduction --;2. Substrate Supply for Haemoglobin Syntheses --;Iron Uptake --;Mechanism of iron supply to erythroid cells --;Factors influencing iron uptake by erythroid cells --;Iron and transferrin levels and transferrin saturation --;Metabolic state of crythroid cells --;The role of sulfhydryl groups in iron uptake --;Other factors which influence iron uptake --;Iron uptake from chelating agents --;Intracellular kinetics of iron --;Ferritin --;Other non-haem iron proteins and iron complexes --;Mitochondrial iron --;Inhibitors of haem synthesis as a tool in investigations of the intracellular kinetics of iron --;Regulation of iron supply for haemoglobin synthesis --;Effect of haem on iron uptake by reticulocytes --;Effort of inhibitors of haem and globin syntheses on iron uptake --;Mechanism of the effcct of haem on iron uptake --;Regulation of Uptake of Glycine and other Amino Acids --;3. Haem Synthesis --;Biosynthesis of Haem --;General introduction --;ALA synthesis --;ALA synthetase --;Porphobilinogen (PBG) synthesis. ALA dehydrase enzyme --;Conversion of porphobilinogen (PBG) to uroporphyrinogen III --;Conversion of uroporphyrinogen to coproporphyrinogen by the enzyme uroporphyrinogen decarboxylase --;Conversion of coproporphynnogen lo protoporphyrinogen by the enzyme coproporphyrinogen oxidase --;Combination of iron with protoporphyrin --;Free protoporphyrin --;Regulation of Haem Biosynthesis --;Enzyme synthesis --;Changes in enzyme activity --;Regulation by substrate supply --;Metabolic and external factors --;Haem catabolism --;4. Globin Synthesis --;Globin Biosynthesis --;General introduction --;Role of ribonucleic acids in globin synthesis --;Messenger RNA --;Isolation and identification of globin mRNA --;Methods used for the isolation of globin mRNA --;Detection of messenger RNA for globin --;Characteristics of globin mRNA --;Biosynthesis of globin mRNA --;Transfer RNA --;Ribosomes and globin synthesis --;Ribosome structure --;The role of polyribosomes --;The role of sub-units --;Membrane-bound ribosomes --;Function of the active ribosomal complex --;Initiation of the globin chain --;Initiation of globin synthesis by means of methionyl-tRNA --;Initiation factors of reticulocyte ribosomes --;Elongation of the globin chain --;Globin chain termination --;Regulation of Globin Synthesis --;Post-transcription control of globin synthesis --;Stability of globin mRNA --;Translation control --;Rate limiting step in the synthesis of the globin chain --;Synchronization of synthesis of different chains --;The role of haem in globin synthesis --;5. Regulation of Haemoglobin Synthesis --;Coordination of Haem and Globin Syntheses --;Regulatory role of haem --;Mutual relations between haem and globin synthesis --;Haemoglobin Synthesis During Maturation --;6. Differentiation of Erythroid Cells --;Erythroid Differentiation in Haematopoietic Tissue and the Initiation of Haemoglobin Synthesis --;Mechamun of erythropoietin action --;Erythroid Differentiation Without Erythropoietin --;7. Anaemias Due to Disorders of Haemoglobinization --;Hypochromic Anaemias Due to Impaired Haem Synthesis --;Hypochromic anaemias caused by a reduced iron supply into erythroid tissue --;Iron deficiency anaemia --;Congenital atransferrinaemia --;Hypochromic anaemia as a result of reduced iron release from reticuloendothelial cells --;Copper defficiency --;Sideroblastic anaemias --;Hypochromic Anaemias Due to Impaired Globin Synthesis --;Thalassaemia --?-thalassaemia --;Haemoglobin Constant Spring and related mutants of the terminal portion of the chain --;ß- and?ß-thalassaemia --;References.
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| Abstract
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During the life span of humans the following haemoglobins are formed: embryonic haemoglobins Gower 1 and 2, foetal haemoglobin F and two adult haemoglobins A and A .
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Hematology.
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Medicine.
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| LC Classification
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QP96.5B956 1977
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| Added Entry
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J Neuwirt
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P Poňka
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