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" Leukolysins and Cancer "
edited by Janet H. Ransom, John R. Ortaldo.
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BL
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| Record Number
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735353
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b555192
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| Main Entry
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edited by Janet H. Ransom, John R. Ortaldo.
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| Title & Author
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Leukolysins and Cancer\ edited by Janet H. Ransom, John R. Ortaldo.
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| Publication Statement
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Totowa, NJ: Humana Press, 1988
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| Series Statement
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Contemporary biomedicine, 8.
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(XVIII, 322 pages).
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| ISBN
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1461245869
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: 9781461245865
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| Contents
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1. Biology and Biochemistry --;Cytolytic Pore-Forming Proteins --;Cytolysin: Its Purification, Biological Properties, and Mechanisms of Action --;Monocyte Cytotoxic Factors --;Triggering of a Cytolytic Factor with TNF-Like Activity From Human Monocytes --;1. Introduction --;2. Results and Discussion --;2.3. Target-Cell Selectivity and Capacity to Induce CM Production in Monocytes --;References --;Antitumor Monocyte Cytotoxic Factors (MCF) Produced by Human Blood Monocytes: Production, Characterization, and Biological Significance --;1. Introduction --;2. Generation of MCF --;3. Lytic Activity of MCF --;4. Biochemical and Biophysical Characteristics of MCF --;5. Biological Significance of MCF --;6. Conclusion --;References --;Antiproliferative Effects of Interferon --;1. Introduction --;2. Structure of Interferon --;3. Interferon Receptors --;4. Mechanisms of Action --;5. In Vitro Antiproliferative Effects --;6. Structure-Function Relationships --;7. In Vivo Tumor Biology --;8. Conclusion --;References --;Natural Killer Cell Cytotoxic Factor --;Human and Rodent Natural Killer Cytotoxic Factors (NKCF): Characterization and Their Role in the NK Lytic Mechanism --;1. Introduction --;2. Materials and Methods --;3. Results and Discussion --;4. Concluding Remarks --;References --;Human Natural Killer Cytotoxic Factor (NKCF): Relevance, Mode of Action, and Relationship to Other Cytotoxic Factors --;1. Introduction --;2. Results --;3. Discussion --;References --;Natural Killer Cell Cytotoxic Factor --;1. Introduction --;2. Biology of NKCF --;3. Biochemistry of NKCF --;4. Mechanism of Action of NKCF --;5. Future Studies --;References --;Leukoregulin --;Leukoregulin: Biology, Biochemistry, and Mode of Action --;1. Introduction --;2. Biology of Leukoregulin --;3. Physicochemical Characteristics of Leukoregulin --;4. Conclusions --;References --;Leukoregulin Mechanisms of Anticancer Action --;1. Discovery of Leukoregulin --;2. Assays Defining Leukoregulin Activity --;3. Preparation of Leukoregulin --;4. Pathways of Leukoregulin Action --;5. Role of Leukoregulin in Homeostasis and Pathophysiology --;6. Therapeutic Implications and Research Directions --;References --;Lymphotoxins: Mediators of Cellular Activation, Inflammation, and Cell Lysis That Are Immunologically Related to Macrophage Toxins and Tumor Necrosis Factors --;1. Introduction --;2. Studies of Lymphotoxin from Normal Lymphocytes --;3. Immunological Relationships of LT-1, LT-2, LT-3, MCT, and TNF --;4. Effects of Lymphotoxins on Cells In Vitro --;5. Antitumor Effects of Lymphotoxins In Vivo --;6. Lymphotoxins as Inducers of Inflammation --;7. Conclusion --;References --;Tumor Necrosis Factors Alpha and Beta: A Family of Biochemically Related Cytokines --;1. History of Tumor Necrosis Factors --;2. Nomenclature: In Vivo Necrosis Activities --;3. HuTNF-? and HuTNF-?: Biochemistry and Molecular Biology --;4. Summary --;References --;2. Clinical Applications Interferons --;Clinical Aspects of Interferon Therapy in Human Cancer --;Antiproliferative and Clinical Antitumor Effects of Interferons --;Biologic Effects of Tumor Necrosis Factors Alpha and Beta --;Leukoregulin: Potential as a Clinical Cancer Therapeutic Agent.
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| Abstract
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This book is intended for both immunologists conducting basic research and clinical oncologists, since it reviews not only the clinical applications of the leukolysins, but presents a current update on those leukolysins that are in early developmental stages of research and could enter into clinical trials in a few years.
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| Subject
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Leukolysins.
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Medicine.
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Oncology.
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| LC Classification
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QR185.8.L49E358 1988
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| Added Entry
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Janet H Ransom
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John R Ortaldo
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| Parallel Title
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Contemporary Biomedicine, vol. 8
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