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" Hypolipidemic Agents "
edited by David Kritchevsky.
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BL
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| Record Number
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738432
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b558345
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| Main Entry
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edited by David Kritchevsky.
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| Title & Author
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Hypolipidemic Agents\ edited by David Kritchevsky.
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| Publication Statement
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Berlin, Heidelberg: Springer Berlin Heidelberg, 1975
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| Series Statement
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Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology,, 41.
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| ISBN
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3642661904
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: 3642661920
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: 9783642661907
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: 9783642661921
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| Contents
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1 Cholesterol Biosynthesis in vitro --;I. Cell-Free Homogenates --;II. Microsomal and Soluble Enzymes; Squalene and Sterol Carrier Protein Applications --;III. Preparations and Activity Assays --;References --;2 Cholesterol Metabolism in Man --;I. Introduction --;II. Distribution of Cholesterol in the Body --;III. Functions of Cholesterol --;IV. Synthesis of Cholesterol --;V. Absorption of Dietary Cholesterol --;VI. Catabolism of Cholesterol and Its Losses from the Body Pools --;VII. Plasma Cholesterol --;VIII. Relationship of Cholesterol in Plasma and Tissue Pools --;IX. Homeostasis of Plasma Cholesterol --;X. Plasma Cholesterol Esters --;XI. Proposed Model for Cholesterol Metabolism in Man --;XII. Cholesterol Metabolism in Hyperlipoproteinemias --;References --;3 Bile Acid Metabolism --;I. Introduction --;II. Enterohepatic Circulation --;III. Different Parameters of Bile Acid Metabolism --;IV. Regulation of Cholesterol Catabolism via Bile Acids --;V. Physiological Factors Influencing Bile Acid Metabolism --;VI. Effects of Hormones on Bile Acids --;VII. Hyperlipidaemia --;References --;4 Mechanisms of Hyperlipidemia --;I. Introduction --;II. Normal Levels of Plasma Triglycerides and Cholesterol --;III. The Plasma Lipoprotein Spectrum --;IV. The Metabolism of Constituents of Plasma Lipoproteins --;V. Classification of Hyperlipidemias --;References --;5 Lipoproteins and Lipoprotein Metabolism --;I. Structure and Functions of Lipoproteins --;II. Synthesis of Lipoproteins --;III. Lipoprotein Metabolism --;IV. The Hyperlipoproteinemias --;V. Treatment of Hyperpoproteinemia --;References --;6 Animal Models for Atherosclerosis Research --;I. Rabbit --;II. Rat --;III. Chicken --;IV. Dog --;V. Pigeons --;VI. Swine --;VII. Primates --;References --;7 Lipoprotein Formation in the Liver Cell (Ultrastructural and Functional Aspects Relevant to Hypolipidemic Action) --;I. Introduction --;II. The Concept of Membrane Flow and Its Relevance to Secretion --;III. Formation and Secretion of Lipoproteins --;IV. Regulation of Lipoprotein Secretion --;V. Concluding Remarks --;References --;8 Vascular Metabolism, Vascular Enzymes, and the Effect of Drugs --;I. Notes on Vascular Metabolism --;II. Vascular Enzyme Studies --;III. The Effect of Drugs --;Concluding Remarks --;Abbreviations --;References --;9 Hypolipidemic Agents --;I. Introduction --;II. The Coronary Drug Project --;III. Nicotinic Acid and Analogs --;IV. Pyrazoles and Isoxazoles --;V. Diethyl Chelidonate --;VI. The Role of the Second Messenger in Lipolysis --;VII. Catecholamines, Adrenergic Blocking Agents --;VIII. Miscellaneous Inhibitors of Lipolysis --;IX. The Prostaglandins --;X. Thyroid Hormones --;XI. Estrogens, Progestagens, Anabolic, and Androgenic Compounds --;XII. Substituted Phenyl- and Phenyloxy-acetic Acids --;XIII. Hepatic Action of Clofibrate and Its Analogs --;XIV. Extrahepatic Enzymes Influenced by Clofibrate --;XV. Potential Antiatherosclerotic Effect of Clofibrate --;XVI. Derivatives of Dialkylaminoethanol --;XVII. Unsaturated Fatty Acids --;XVIII. Compounds Containing Sulfur --;XIX. Indole-2-Carboxylic Acids --;XX. Hydroxylamine Derivatives --;XXI. Pyridinolcarbamate --;XXII. Eritadenine --;XXIII. Miscellaneous Compounds --;XXIV. Cholestyramine --;XXV. Neomycin --;XXVI. Rifampin --;XXVII. Concluding Remarks --;References --;10 The Rationale for Hypolipemic Therapy --;Cholesterol Lowering by Diet --;Conclusions from the Dietary Trials --;Cholesterol Lowering with Clofibrate --;Extrapolations between Different Lipid Lowering Techniques --;Summary of Opinions --;Conclusions --;References --;Author Index.
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| Abstract
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The major cause of death in the Western world is some form of vascular disease; The contributions to this book include descriptions of cholesterol synthesis and metabolism, as well as the metabolism of bile acids, the principal products of cholesterol metabolism.
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| Subject
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Medicine.
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| Subject
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Pharmacy.
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| LC Classification
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R1.E358 1975
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| Added Entry
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David Kritchevsky
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