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" The Tetracyclines "
edited by J.J. Hlavka, J.H. Boothe.
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BL
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| Record Number
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739605
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b559535
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| Main Entry
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edited by J.J. Hlavka, J.H. Boothe.
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| Title & Author
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The Tetracyclines\ edited by J.J. Hlavka, J.H. Boothe.
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| Publication Statement
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Berlin, Heidelberg: Springer Berlin Heidelberg, 1985
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| Series Statement
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Handbook of Experimental Pharmacology, Continuation of Handbuch der experimentellen Pharmakologie,, 78.
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| ISBN
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3642703046
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: 3642703062
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: 9783642703041
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: 9783642703065
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| Contents
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1 Historical Introduction --;References --;2 Fermentation and Mutational Development of the Tetracyclines --;A. Introduction --;B. The Producing Microorganisms --;C. The Fermentation Process --;D. Fermentation Technology --;E. Concluding Remarks --;References --;3 Structure Determination and Total Synthesis of the Tetracyclines --;A. Introduction --;B. Structure Determination --;C. Partial Synthesis from Derivatives --;D. Total Synthesis of Tetracycline Derivatives and Incomplete Syntheses --;E. Total Synthesis of 6-Demethyl-6-deoxytetracycline --;F. Total Synthesis of Fermentation Tetracyclines --;G. Total Synthesis of Tetracycline Analogues --;References --;4 Biosynthesis of the Tetracyclines --;A. Introduction --;B. Production Strains --;C. Building Units of Tetracyclines --;D. The Biosynthetic Pathway of Tetracyclines --;E. Regulation of the Biosynthesis of Tetracyclines --;E. Regulation of the Biosynthesis of Tetracyclines --;F. Biosynthesis of Macromolecules and the Production of Tetracyclines --;G. Conclusion --;References --;5 Chemical Modification of the Tetracyclines --;A. Introduction --;B. Semisynthetic Tetracyclines --;C. Totally Synthetic Unnatural Tetracyclines --;D. Overall Structure-Activity Relationships --;References --;6 Mode of Action of the Tetracyclines and the Nature of Bacterial Resistance to Them --;A. Introduction --;B. Mode of Action of the Tetracyclines: Studies Before 1964 --;C. Current Views on the Nature of Bacterial Protein Synthesis --;D. Effects of Tetracyclines on Protein Synthesis in Prokaryotes --;E. Binding of Tetracyclines to Macromolecules --;F. Molecular Basis of Tetracycline Action --;G. Relation Between Structure and Activity in the Tetracyclines --;H. Effects of Growth in the Presence of Low Tetracycline Concentrations on Microbial Metabolism --;I. Selective Toxicity of the Tetracyclines --;J. Transport of Tetracyclines into Bacteria --;K. Plasmid-Determined Resistance to the Tetracyclines --;L. Chromosomal Mutation to Tetracycline Resistance --;M. Conclusions --;References --;7 Clinical Uses of the Tetracyclines --;A. Antimicrobial Activity --;B. Clinical Uses --;C. Treatment of First Choice --;D. Effective Alternative Treatment --;E. Treatment of Clinical Syndromes --;F. Ineffective Treatment --;G. Dosage and Duration of Therapy --;References --;8 Nonmedical Uses of the Tetracyclines --;A. Historical --;B. Growth Promotion and Improved Feed Efficiency in Livestock --;C. Disease Prevention Effects of Chlortetracycline and Oxytetracycline --;D. Public Health Considerations --;E. Government Restrictions --;References.
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| Abstract
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The history of antibiotics may weIl have begun with the ancient Sudanese-Nubian civilization (see Chapter 1, "Historical Introduction"), but this volume reflects a more contemporary appraisal of the antibiotic era. Pearl River, NY J OSEPH J. 3 CHAPTER 2 Fermentation and Mutational Development of the Tetracyclines J.
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| Subject
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Medicine.
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Pharmacy.
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Toxicology.
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| LC Classification
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RM666.T33E358 1985
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| Added Entry
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J H Boothe
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J J Hlavka
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